Gene Targeting Studies of Hyperexcitability and Affective States of Alcohol Withdrawal in Rodents

Greenberg, Gian D.; Crabbe, John C.

doi:10.1016/bs.irn.2016.02.010

Cited by 6 publications

(2 citation statements)

References 106 publications

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“…Similar to the first caveat, especially since most of the transgenic work has involved mice, this was done due to space limitations. For excellent discussions on both of these subjects see Barkley-Levenson and Crabbe (2014), Bilbao (2013), Crabbe et al (2006), Fisch and Flint (2006), Greenberg and Crabbe (2016), Kalueff and Bergner (2010), Mayfield et al (2016), as well as Oberlin et al (2011). Third, models of withdrawal, and to some degree dependence, as well as stress and its associated medications screening received limited review.…”

Section: Caveats Challenges and Conclusionmentioning

confidence: 99%

“…To a great extent this is also related to the first caveat, in the sense that most of the ethanol withdrawal research has been conducted in mice. We noted some of the rat research, often using outbred rat lines, in section 4.8 and Table 8; for other work and discussion see Al’Absi (2007), Becker (2013), Burke and Miczek (2014), Greenberg and Crabbe (2016), Lopez and Becker (2014), Metten et al (2014), Phillips et al (2015), Spanagel et al (2014a), Vendruscolo and Roberts (2014), as well as Zorrilla et al (2014).…”

Section: Caveats Challenges and Conclusionmentioning

confidence: 99%

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Rat animal models for screening medications to treat alcohol use disorders

et al. 2017

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The purpose of this review is to present animal research models that can be used to screen and/or repurpose medications for the treatment of alcohol abuse and dependence. The focus will be on rats and in particular selectively bred rats. Brief introductions discuss various aspects of the clinical picture, which provide characteristics of individuals with alcohol use disorders (AUDs) to model in animals. Following this, multiple selectively bred rat lines will be described and evaluated in the context of animal models used to screen medications to treat AUDs. Next, common behavioral tests for drug efficacy will be discussed particularly as they relate to stages in the addiction cycle. Tables highlighting studies that have tested the effects of compounds using the respective techniques are included. Wherever possible the Tables are organized chronologically in ascending order to describe changes in the focus of research on AUDs over time. In general, high ethanol-consuming selectively bred rats have been used to test a wide range of compounds. Older studies usually followed neurobiological findings in the selected lines that supported an association with a propensity for high ethanol intake. Most of these tests evaluated the compound's effects on the maintenance of ethanol drinking. Very few compounds have been tested during ethanol-seeking and/or relapse and fewer still have assessed their effects during the acquisition of AUDs. Overall, while a substantial number of neurotransmitter and neuromodulatory system targets have been assessed; the roles of sex- and age-of-animal, as well as the acquisition of AUDs, ethanol-seeking and relapse continue to be factors and behaviors needing further study.

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