“…Replacement therapy, with the administration of the missing factor, remains a cornerstone in the management of congenital hemophilia, to treat both bleeding and prophylactically [ 5 ]. Patients with congenital HA and HB have a variety of therapeutic options, including gene and cellular therapies [ 6 , 7 ]. Progressive joint disease, the development of inhibitors, increased risk of cardiovascular disease (CVD), infections, and severe bleeding constitute complications of these clinical entities, leading to increased mortality and morbidity [ 8 , 9 , 10 , 11 , 12 ].…”