Gene Therapy for the Treatment of Chronic Wounds

García-Fuentes, Marcos

doi:10.1002/9781119433316.ch10

Cited by 4 publications

(3 citation statements)

References 121 publications

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“…Gene augmentation, as a prominent strategy, addresses deficiencies resulting from impaired genes in wounds and facilitates the expression of specific proteins crucial for wound healing 88 . Gene augmentation regulates angiogenesis in wound healing and can be achieved by inserting DNA or mRNA into the target cells.…”

Section: Gene Therapy‐based Skin Substitutesmentioning

confidence: 99%

“…86 We designed and synthesised a multi-functional pro-angiogenic molecule by grafting LXW7 and collagen-binding peptides (SILY) to a dermatan sulfate Gene augmentation, as a prominent strategy, addresses deficiencies resulting from impaired genes in wounds and facilitates the expression of specific proteins crucial for wound healing. 88 Gene augmentation regulates angiogenesis in wound healing and can be achieved by inserting DNA or mRNA into the target cells. Key signalling pathways crucial for wound healing encompass those triggered by FGF, VEGF, transforming growth factor β1 (TGF-β1), hypoxiainducible factor-1α (HIF-1α) and platelet-derived growth factor (PDGF).…”

Section: Peptidesmentioning

confidence: 99%

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Development of pro‐angiogenic skin substitutes for wound healing

Song,

Hao,

Zhou

et al. 2024

Wound Repair Regeneration

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Wounds pose significant challenges to public health, primarily due to the loss of the mechanical integrity and barrier function of the skin and impaired angiogenesis, causing physical morbidities and psychological trauma to affect patients. Reconstructing the vasculature of the wound bed is crucial for promoting wound healing, reducing scar formation and enhancing the quality of life for patients. The development of pro‐angiogenic skin substitutes has emerged as a promising strategy to facilitate vascularization and expedite the healing process of burn wounds. This review provides an overview of the various types of skin substitutes employed in wound healing, explicitly emphasising those designed to enhance angiogenesis. Synthetic scaffolds, biological matrices and tissue‐engineered constructs incorporating stem cells and primary cells, cell‐derived extracellular vesicles (EVs), pro‐angiogenic growth factors and peptides, as well as gene therapy‐based skin substitutes are thoroughly examined. The review summarises the existing challenges, future directions and potential innovations in pro‐angiogenic dressing for skin substitutes. It highlights the need for continued research to develop new technologies and combine multiple strategies and factors, and to overcome obstacles and advance the field, ultimately leading to improved outcomes for wound patients.

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Section: Gene Therapy‐based Skin Substitutesmentioning

confidence: 99%

Section: Peptidesmentioning

confidence: 99%

Development of pro‐angiogenic skin substitutes for wound healing

Song,

Hao,

Zhou

et al. 2024

Wound Repair Regeneration

View full text Add to dashboard Cite

show abstract

“…23 , 24 It can offer selective correction of critical angiogenesis pathways that are dysregulated or defective at their genetic roots. 25 The most commonly explored therapeutic molecules for the modulation of gene expression include plasmid DNA (pDNA) and messenger RNA (mRNA) for overexpression of genes, and smaller short interfering RNA (siRNA), microRNA (miRNA), oligonucleotides, and aptamers for post-translational gene silencing. 26 In addition, the gene-editing tool clustered regularly interspaced short palindromic repeats (CRISPR) is boosting the development of new gene-therapy-based medicines.…”

Section: Introductionmentioning

confidence: 99%