Gene Therapy in Radiotherapy of Cancer

Greenberger, Joel S.; Epperly, Michael W.

doi:10.1016/b978-0-12-394295-1.00009-3

Cited by 2 publications

(2 citation statements)

References 115 publications

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“…However this therapy is not elemental as it also damages the normal undamaged cells. The implication of clinical gene therapy however works by "numerator to denominator of therapeutic ratio" concept where tumour cell kills outweigh the normal tissue damage [12].…”

Section: Edge Over Conventional Therapiesmentioning

confidence: 99%

Autologous Gene Therapy - A Proactive Approach to Cancer Critique

Ahmad¹

2014

J Cancer Sci Ther

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Gene therapy has a vast range of applications not only restricted to AbstractCancer is one of the most prevalent diseases that affect the major population with each year the frequency is increasing exponentially. Patients with diagnosed cancer are generally treated with the conventional therapies like radiation therapy, chemotherapy. However the survival rate and the life span are known to prolonged, these therapies are quite problematic let alone their detrimental side effects. Gene therapy on the other hand is quite promising since the body's immune response is not compromised while targeting the cancerous cell. While getting further insights into the complex pathways and mechanisms associated with the development of malignant cells has led to the identification more sophisticated and specified cancer therapies, it nevertheless remains imperative to execute the conventional therapies and the associated anticancer drug molecules. Various characteristic features like less toxicity and ability to induce an immune response make the therapy quite probable for various cancers like pancreatic, ovarian and Glioblastoma. Based on the results obtained from pre-clinical studies in model animals, it has set stage for the commercialization of the human trials. The advantages associated with this therapy for the treatment has started attracting focus to further modify and optimize the procedures for better results.

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Section: Edge Over Conventional Therapiesmentioning

confidence: 99%

Autologous Gene Therapy - A Proactive Approach to Cancer Critique

Ahmad¹

2014

J Cancer Sci Ther

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“…Although localized cancers may be successfully treated resorting to radiation therapy [18] and/or surgery [32], chemotherapy is the standard treatment for advanced or metastasized cancer. Nonetheless, commonly used chemotherapeutic agents, such as doxorubicin and cisplatin, inadvertently induce damage in healthy cells and tissues, resulting in numerous deleterious side-effects [16].…”

Section: Introductionmentioning

confidence: 99%

Anti-tumoral activity of human salivary peptides

et al. 2015

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Chemotherapy continues to be the standard treatment for advanced or metastasized cancer. However, commonly used chemotherapeutic agents may induce damage in healthy cells and tissues. Thus, in recent years, there has been an increased focus on the development of new, efficient anticancer drugs exhibiting low toxicity and that are not affected by mechanisms of chemoresistance. In the present work, we tested synthetic and naturally obtained human salivary peptides against breast, prostate, colon, osteosarcoma and bladder cancer cell lines (T47-D, PC-3, HT-29, MG63, T-24, respectively). Results have showed that there is a reduced cell population increase that is peptide-, cell- and possibly pathway-specific, with the most potent effect observed in observed in T-47D breast cancer cells. Protein expression and microscopy results further indicate that, in this cell line, the peptide with the sequence GPPPQGGRPQG (GG peptide) interferes with the ability of cell adhesion proteins to stabilize adherens junctions, such as E-cadherin, leading to apoptosis. These promising results encourage future works aimed at disclosing the vast potential of salivary peptides as new therapeutic agents.

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Gene Therapy in Radiotherapy of Cancer

Cited by 2 publications

References 115 publications

Autologous Gene Therapy - A Proactive Approach to Cancer Critique

Autologous Gene Therapy - A Proactive Approach to Cancer Critique

Anti-tumoral activity of human salivary peptides

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