Gene therapy may benefit inherited ichthyoses with concurrent fungal infections and severe ich thyroidoses

2021

Preprint

Global Initiative for Chronic Obstructive Lung Disease (GOLD) research on chronic obstructive pulmonary condition (COPD) characterizes it as a prevalent, preventable, and curable illness with persistent respiratory symptoms and airflow limitation. airway blockage resulting in dyspnoea and air trapping when exercising airflow restriction can be attributed to smoking, ambient tobacco smoke exposure, and the patient's TB history COPD airflow restriction is largely caused by airway tightness, chronic bronchitis, or emphysema. Repeated inhalation of hazardous particles induces chronic inflammatory immune cell infiltration, tissue repair, and airway remodeling, resulting in a 4-to 40-fold increase in airway resistance and bronchiolar constriction. 20% of small airways are bronchi, with the rest being either bronchioles or alveolar ductal gaps. Flow restriction includes alveolar wall disintegration and alveolar support. The modifications worsen the rapid FEV1 fall and contribute to the airway obstruction seen in COPD. COPD, small airway disease (SAD), has been extensively studied. Inflammation, fibrosis, and destruction of bronchioles are all indications of this illness. mixed pulmonary fibrosis and emphysema (CPFE). In fact, fibrosis appears to be involved in the obstruction of small airways.RAGE participates in several intracellular processes by binding to several ligands. RAGE ligand interactions trigger downstream signaling pathways that have been associated with COPD and other disorders. Thus, inhibitors of RAGE and its signaling pathways also have been found to play a function in other disorders, which suggests that they might be used to treat COPD. There are currently no established biomarkers to diagnose COPD. COPD patients are shown to have altered RAGE and some of its ligands. Despite a lack of agreement on how smoking affects sRAGE levels, greater study is needed to discover whether or not this biomarker is stable. It was discovered that among the North Han Chinese,-429T > C is associated with COPD. COPD vulnerability is furthermore associated with the genetics of RAGE. To get a better diagnosis, population-based studies are needed. Finally, RAGE, AGE-RAGE, and sRAGE all impact COPD, and RAGE may be employed as a biomarker for diagnosis and management of COPD patients if more study supports this hypothesis.

Section: Other Biomarkers For Copdmentioning

confidence: 99%

Chronic obstructive pulmonary condition (COPD) is a prevalent, preventable, and curable illness with persistent respiratory symptoms and airflow limitation

2021

Preprint

“…Li et al also achieved allele-specific gene editing in the retinas of Rho-P23H knock-in mice (88), which targeted the P23H allele with a single-nucleotide alteration. Shinmyo et al also used in utero electroporation to transfer a plasmid containing CRISPR/Cas components into the mouse brain for successful brain-specific gene editing in vivo (89). These studies proved the viability of CRISPR/Cas9 delivery through DNA in vivo.…”

Section: Crispr/cas Gene Editing and Delivery Without The Use Of Virusesmentioning

confidence: 99%

CRISPR/Cas system research has advanced significantly in biological sciences.There are still many challenges to effective delivery before efficient gene editing may be achieved

2021

Preprint

The CRISPR/Cas system's discovery and execution offer great promise for the treatment of human illnesses and the revolutionization of plant breeding. Despite the fact that CRISPR/Cas system research is well advanced in the life sciences community, there are still considerable barriers to effective delivery that must be overcome before effective gene editing can be achieved. Consider characteristics like specificity, efficacy, and controlled expression while deciding on a plan. Due to the discovery of innovative delivery systems, many of the shortcomings of the CRISPR/Cas system's translatability have been addressed. Because of the rapid growth of delivery mechanisms, a successful translation of CRISPR/Cas technology into medical and agricultural applications is vital, and substantial progress is predicted.

“…Interferons (IFNs) are another well-known cytokine used in cancer treatment. IFNs are a protein and glycoprotein family having antiviral, antiproliferative, and immunomodulatory properties (89). IFNs are categorised according to their capacity to bind to certain receptors.…”

Section: In Cancer Immunotherapy Cytokines Play An Important Rolementioning

confidence: 99%

Mesenchymal stem cells strategies in cancer immunotherapy

2021

Preprint

Mesenchymal stem cells (MSCs) have been a new research focus for cancer treatment. Future cancer sufferers will considerably profit from their use in the future. Tumor-directed migratory and integration capacities of MSCs are exceptional, making them potential carriers for the delivery of anticancer medicines, notably cytokines. Their usage in the clinic has lasted around 10 years. The use of mesenchymal stem cells (MSCs) to create successful cancer treatments has been demonstrated in everything from animal models to human studies.