Gene Therapy of Arthritis.

Evans, Christopher H.; Robbins, Paul D.

doi:10.2169/internalmedicine.38.233

Cited by 44 publications

(15 citation statements)

References 45 publications

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“…Another potential therapeutic use of antiinflammatory cytokines is in the treatment of rheumatoid arthritis, an inflammatory disease of the joints. Several gene therapy vectors have been tested in animal models for arthritis (reviewed in [124,125]). Gene delivery of TGF-beta 1, IL-4, and the EBV homologue of IL-10 (vIL-10) have all shown some degree of efficacy.…”

Section: Applications Of Anti-inflammatory Cytokine Vectorsmentioning

confidence: 99%

Gene Vectors for Cytokine Expression In Vivo

Hitt

Gauldie²

2000

CPD

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The understanding of cytokine networks and the exploitation of these networks for the treatment of immune and inflammatory diseases as well as cancer depend on in vivo delivery of cytokines. Due to instability of recombinant cytokine proteins, investigators have employed cytokine-encoding gene therapy vectors to induce high levels of cytokine expression in vivo. Numerous gene therapy vectors have been developed recently which are suitable for this purpose. Recent advances in the design of adenovirus, adeno-associated virus, poxvirus, retrovirus, lentivirus, and nonviral vectors are described here. Properties of the various vector systems which determine their usefulness for cytokine gene delivery are compared. The implementations of cytokine-encoding gene therapy vectors for analyzing immune responses and for the therapy of inflammatory disorders, immune disease, infections and cancer are reviewed.

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Section: Applications Of Anti-inflammatory Cytokine Vectorsmentioning

confidence: 99%

Gene Vectors for Cytokine Expression In Vivo

Hitt

Gauldie²

2000

CPD

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“…A variety of genes that code for antiarthritic proteins are under investigation, including IL-1Ra, IL-1sR, TNFsR, transforming growth factor β (TGFβ), IL-13, Fas L, IL-10, and vIL-10, as are the vectors that will carry them to arthritic tissues 29 . Already, two human arthritis gene therapy protocols are underway in the US and Germany, with ex vivo transfer of an IL-1Ra cDNA to the metacarpophalangeal joints of patients with RA.…”

Section: Diseasesmentioning

confidence: 99%

Arthritis

2000

Nat Biotechnol

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“…A variety of genes that code for antiarthritic proteins are under investigation, including IL-1Ra, IL-1sR, TNFsR, transforming growth factor b (TGFb), IL-13, Fas L, IL-10, and vIL-10, as are the vectors that will carry them to arthritic tissues 25 . Already, two human arthritis gene therapy protocols are underway in the US and Germany, with ex vivo transfer of an IL-1Ra cDNA to the metacarpophalangeal joints of patients with RA.…”

Section: The Futurementioning

confidence: 99%

Arthritis drug discovery

Persidis

1999

Nat Biotechnol

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Gene Therapy of Arthritis.

Cited by 44 publications

References 45 publications

Gene Vectors for Cytokine Expression In Vivo

Gene Vectors for Cytokine Expression In Vivo

Arthritis

Arthritis drug discovery

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