Gene Variants of the SLC2A5 Gene Encoding GLUT5, the Major Fructose Transporter, Do Not Contribute to Clinical Presentation of Acquired Fructose Malabsorption.
Abstract:Background: While role of ALDOB-related gene variants for hereditary fructose intolerance is well established, contribution of gene variants for acquired fructose malabsorption (e.g. SLC2A5, GLUT5) is not well understood.Methods: Patients referred to fructose breath test were further selected to identify those having acquired fructose malabsorption. Molecular analysis included (I) exclusion of three main ALDOB gene variants causing hereditary fructose intolerance and (II) sequencing analysis of genomic region … Show more
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