Genel Anesteziye Altındaki Gebe Tavşanlarda Rocuronium ve Sugammadex’in Progesteron Düzeyine Etkisi

Abstract

The purpose of this study was to investigate the effect of rocuronium and sugammadex on progesterone (P4) levels in pregnant rabbits under general anesthesia. Twenty-one pregnant New Zealand rabbits were used in the study. After the rabbits were divided into three groups of three (Control, Group I and Group II), each animal was given 0.5 mg/kg midazolam and 6 mg/kg propofol and then put under general anesthesia with sevoflurane on the 21 st day of pregnancy. No procedure was performed on the control group apart from anesthesia. Rocuronium was administered to GI at the onset of anesthesia, and in GII, sugammadex was administered 60 min after general anesthesia + rocuronium. All of the rabbits were monitored during the anesthesia procedure. A sample of venous blood was taken and biochemically analyzed to test P4 levels. The administration of rocuronium was determined to have caused an increase in the serum progesterone level in all recorded min. Sugammadex was found to cause a quantitative decrease in the level of progesterone. In conclusion, it was found out that rocuronium and sugammadex administration did not have a negative effect on progesterone levels in pregnant rabbits receiving general anesthesia.

What we need to know and do on sugammadex usage in pregnant and lactating women and those on hormonal contraceptives

“…Two animal studies that investigated the effect of sugammadex on progesterone levels in pregnant animals have been conducted [ 25 , 26 ]. Pregnant rats were randomly assigned to three groups and injected under sedation on the 7th day of gestation: control, sugammadex 30 mg/kg, and rocuronium 3.5 mg/kg + sugammadex 30 mg/kg [ 25 ].…”

“…Progesterone levels were not significantly different between the groups, and successful completion of pregnancy and absence of stillbirths or miscarriages were reported. Pregnant rabbits were randomly divided into three groups: control, rocuronium administered at the onset of general anesthesia (GI group), and rocuronium + sugammadex administered 60 min after general anesthesia (GII group) [ 26 ]. In the GII group, progesterone levels at 60 and 90 min after general anesthesia were significantly lower than the baseline progesterone levels.…”

Ratlarda Sugammadex ve Rocuronium Kombinasyonunun Kraniyal Nörotoksisite Üzerine Etkisi: Deneysel Çalışma

“…Rocuronium is the most commonly used steroid-building agent in non-depolarizing muscle relaxants. In order to regain the muscle functions of the patient and prevent residual neuromuscular block, it is necessary to remove the effect of the muscle relaxant agents temporarily [2,3] . Classic  İletişim (Correspondence)  +90 416 2231690 Fax: +90 416 2231693  uludagoznur@gmail.com reversal agents, such as neostigmine, implement their activity by raising the levels of Ach at the neuromuscular junction by competitive inhibition of Ach-esterase.…”