General and reproductive health outcomes among female greenhouse workers: a comparative study

Rahimi, Tahereh; Rafati, Foozieh; Sharifi, Hamid; Seyedi, Fatemeh

doi:10.1186/s12905-020-00966-y

Cited by 18 publications

(25 citation statements)

References 36 publications

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“…The significantly higher number of PN born by mothers with a rural residence detected in our study is in concordance with previous studies [26][27][28][29]. The origin of such an association may lie in the fact that many pesticides, most likely also used in the rural areas from which the mothers came, are endocrine disruptors with a wide range of effects on oestrogen and androgen receptors and aromatase [30].…”

Section: Discussionsupporting

confidence: 92%

Comparison of Estradiol, Testostosterone, and CYP19 Methylation Levels between Full-Term and Preterm Newborns

et al. 2021

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Estradiol (E), testosterone (T), and their ratio are crucial axis in life. Especially during intrauterine growth, they orchestrate the complex development of organs and their interaction, which have lifelong impact on health and an organism’s capacity to respond to environmental stressors. The aim of this study was to compare for the first time E, T, and their ratio levels with aromatase (CYP19) gene methylation levels between preterm newborns (PN) and full-term newborns (FN) with respect to their mother’s environmental exposure and diet. In this study, 56 FN of 37–42 weeks of gestation age (GA) and 46 PN at GA 27–36 weeks were analysed for E and T levels and CYP19A1 gene pI.3/II promoter region methylation. Results showed there was no difference in E levels between PN and FN, but there were significantly lower levels of T in PN than in FN (2.81 nmol vs. 3.76 nmol, respectively) and consequently a significantly higher E/T ratio in PN than in FN (5278.04 vs. 2891.23, respectively). CYP19A1 methylation was significantly lower in PN than in FN (86.04% vs. 90.04%, respectively). CYP19A1 methylation was significantly reduced in newborns whose mothers reported daily milk consumption. Our study is the first to provide referent values for CYP19A1 methylation levels in FN and PN and shows that PN and FN significantly differ in CYP19A1 methylation levels, T levels, and E/T ratio. Future research should further investigate the mechanisms involved in GA-dependent CYP19A1 methylation levels and mechanisms of sex hormone disturbances which may contribute to preterm birth.

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Section: Discussionsupporting

confidence: 92%

Comparison of Estradiol, Testostosterone, and CYP19 Methylation Levels between Full-Term and Preterm Newborns

et al. 2021

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“…Rahimi et al interviewed women working in greenhouses and married for at least one year, with 338 unexposed controls from nearby villages, in a cross-sectional study from southern Iran [44]. The women were 16-49 years of age.…”

Section: Spontaneous Fetal Loss (Miscarriage)mentioning

confidence: 99%

Reproductive Health Risks Associated with Occupational and Environmental Exposure to Pesticides

Fučić

Duca

Galea

et al. 2021

IJERPH

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A marked reduction in fertility and an increase in adverse reproductive outcomes during the last few decades have been associated with occupational and environmental chemical exposures. Exposure to different types of pesticides may increase the risks of chronic diseases, such as diabetes, cancer, and neurodegenerative disease, but also of reduced fertility and birth defects. Both occupational and environmental exposures to pesticides are important, as many are endocrine disruptors, which means that even very low-dose exposure levels may have measurable biological effects. The aim of this review was to summarize the knowledge collected between 2000 and 2020, to highlight new findings, and to further interpret the mechanisms that may associate pesticides with infertility, abnormal sexual maturation, and pregnancy complications associated with occupational, environmental and transplacental exposures. A summary of current pesticide production and usage legislation is also included in order to elucidate the potential impact on exposure profile differences between countries, which may inform prevention measures. Recommendations for the medical surveillance of occupationally exposed populations, which should be facilitated by the biomonitoring of reduced fertility, is also discussed.

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“…Numerous studies have shown that occupational exposure or residence near agricultural environments where pesticides are frequently used confers a higher risk of adverse reproductive health outcomes (Shirangi et al 2008 ; Naidoo et al 2011 ; Razi et al 2016 ; Settimi et al 2008 ; Rahimi et al 2020 ). In the few studies that found no such association (Bell et al 2001 ; Willis et al 1993 ), dietary zinc intake might not have been considered.…”

Section: Discussionmentioning

confidence: 99%

Dietary zinc intake and body mass index as modifiers of the association between household pesticide exposure and infertility among US women: a population-level study

Huang

Yang

2022

Environ Sci Pollut Res

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Clinical studies on the relationship between pesticide exposure at home and infertility in the general population are scarce. Whether the antioxidant nutrients or other health-related factors affect the pesticide–infertility relationship remains unknown. This nationwide study screened 29,400 participants of the National Health and Nutrition Examination Surveys conducted between 2013 and 2018. The participants were subdivided according to dietary zinc intake based on the recommended dietary allowances as the low-zinc and high-zinc groups (< 8 and ≥ 8 mg/day, respectively), and according to body mass index (BMI; cut-off 28 kg/m 2 ) as the low-BMI and high-BMI groups. Participants who were exposed to pesticides at home had an increased risk of infertility (odds ratio [OR] = 1.56, 95% confidence intervals [CI]: 1.06–2.29). The incidence of infertility differed in low-zinc and high-zinc groups (OR, 95% CI: 2.38, 1.40–4.06 vs. 0.98, 0.53–1.79, respectively), indicating an interaction between pesticide exposure and zinc intake in households ( P = 0.047), which suggests that a zinc-rich diet may reduce the risk of pesticide-induced infertility. Similarly, the relationship between pesticide exposure and infertility risk differed in the low-BMI and high-BMI groups (OR, 95% CI: 0.90, 0.42–1.93 vs. 2.23, 1.39–3.58, respectively; P = 0.045), suggesting that high BMI may intensify the infertility risk caused by pesticide exposure. These new findings reveal the antagonistic and synergistic effect of zinc and obesity, respectively, in pesticide-induced infertility risk and suggest that individuals who are obese and on a low-zinc diet may be more susceptible to infertility induced by household pesticide exposure. Supplementary Information The online version contains supplementary material available at 10.1007/s11356-022-23629-x.

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General and reproductive health outcomes among female greenhouse workers: a comparative study

Cited by 18 publications

References 36 publications

Comparison of Estradiol, Testostosterone, and CYP19 Methylation Levels between Full-Term and Preterm Newborns

Comparison of Estradiol, Testostosterone, and CYP19 Methylation Levels between Full-Term and Preterm Newborns

Reproductive Health Risks Associated with Occupational and Environmental Exposure to Pesticides

Dietary zinc intake and body mass index as modifiers of the association between household pesticide exposure and infertility among US women: a population-level study

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