General and Skin-Specific Health-Related Quality of Life in Patients With Atopic Dermatitis Before and During the COVID-19 Pandemic

Koszorú, Kamilla; Hajdu, K.; Brodszky, Valentin; Szabó, Ákos; Borza, Júlia; Bodai, Katalin; Pónyai, Györgyi; Szegedi, Andrea; Sárdy, Miklós; Rencz, Fanni

doi:10.1097/der.0000000000000908

Cited by 16 publications

(7 citation statements)

References 76 publications

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“…AD prevalence is increasing globally 1 and places a notable burden on patients and their families. 4 This heterogeneous disease is characterized by its variable intensity, extent of lesions and frequency and intensity of clinical symptoms. 5 In our study, we performed a structured web-based survey including 1,650 AD pediatric and adult patients from Argentina.…”

Section: Discussionmentioning

confidence: 99%

“… 3 These harmful effects include domains as emotional and mental health, physical activity, social functioning, sleep quality, work productivity, leisure activities and personal and family relationships. 4 AD has been associated with worse quality of life than several common chronic illnesses (heart disease, diabetes mellitus and hypertension). 5 However, studies about quality of life on Latin American AD patients are scarce and have generally included few patients.…”

Section: Introductionmentioning

confidence: 99%

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Impact of atopic dermatitis on quality of life: a large web-based survey from Argentina

Echeverría¹,

Angles

Larralde

et al. 2022

Rev Fac Cien Med Univ Nac Cordoba

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Background: Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin condition that is associated with detrimental effects on the lives of patients and their families, including an impact on quality of life (QOL). Studies about QOL on Latin American AD patients are scarce and have generally included few patients. Objective: describing AD impact on the QOL in a large cohort in Argentina. Methods: a structured web-based survey including 1,650 AD pediatric and adult patients was performed. Results: according to retrieved data, AD symptoms onset started during childhood in most patients, but 20 % of participants reported that manifestations of AD were initially perceived during late adolescence and adulthood. Important differences were observed among country regions, with a shorter time-to-diagnosis in most populated and richer districts. Main affected domains included frustration, anger, mood alterations, stress, sleep alterations, routine alterations, pain and economic impact of AD. Limitations: biases inherent to survey design. Conclusions: we consider that our study contributes to a better understanding of AD in Argentina, as well as its physical, social and financial impact on affected patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of atopic dermatitis on quality of life: a large web-based survey from Argentina

Echeverría¹,

Angles

Larralde

et al. 2022

Rev Fac Cien Med Univ Nac Cordoba

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“…The EQ-5D questionnaire is the most commonly used generic preference-weighted questionnaire to measure HRQoL in dermatology that showed a good validity in most several dermatological conditions, including AD. [20,21,[24][25][26][27]. The bands that can be used to categorize DLQI scores are as follows: 0-1: no effect on patient's life, 2-5: small effect, 6-10: moderate effect, 11-20: very large effect, and 21-30: extremely large effect [28].…”

Section: Study Samplementioning

confidence: 99%

“…A cross-sectional study was conducted at three two academic dermatology departments and one dermatology outpatient clinic in Hungary between February 2018 and January 2021 [20,21]. Consecutive patients over 18 years of age diagnosed with atopic dermatitis were enrolled.…”

Section: Study Samplementioning

confidence: 99%

Cost-of-illness of adult atopic dermatitis from a societal perspective in Hungary

Beretzky

Koszorú

Rencz

et al. 2023

Preprint

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Introduction: Cost-of-illness studies are widely used for healthcare decision-making in chronic conditions. Our aim was to assess the cost-of-illness of adult atopic dermatitis (AD) from the societal perspective in Hungary. Areas covered: We conducted a multicentre, cross-sectional questionnaire survey. Consecutive AD patients aged ≥18 years were recruited at dermatology departments in Hungary. We calculated direct and indirect costs, including costs for treatments, outpatient visits, hospital admissions, informal care, travel costs and productivity loss. Generalized linear model was used to analyse predictors of total, direct and indirect costs. Expert Commentary: Altogether 218 patients completed the survey (57.8% female) with an average age of 31.3 (SD=11.7). Patients’ average Dermatology Life Quality Index (DLQI) score was 13.5 (SD=8.5). According to Eczema Area and Severity Index (EASI) score, 2.3% (n=5), 21.2% (n=46), 54.4% (n=118) and 22.1% (n=48) had clear, mild, moderate, and severe AD, respectively. We found that the average total, direct medical, direct non-medical and indirect annual costs per patients were €4,331, €1,136, €747, and €2450, respectively, with absenteeism and presenteeism being the main cost drivers, accounting for 24% and 29% of the total cost of AD. A one-year longer disease duration led to, on average, 1.6%, and 4.2% increase in total and direct non-medical costs, respectively. Patients with worse health-related quality of life (higher DLQI score) had significantly higher total, direct medical, direct non-medical costs, and indirect costs. Our results indicate a substantial economic burden of AD from a societal perspective, mainly driven by productivity losses.

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“…12,13 The quality of life for patients with AD is severely affected by sleep disturbances, emotional and mental health problems, and issues with social functioning. 14 In addition, adolescents struggling with body image may develop low perceived happiness and increased stress as chronic and repeat inflammatory reactions cause esthetic and functional skin changes. 15 The negative social and psychological changes experienced by adolescents can lead to depression and anxiety.…”

Section: Introductionmentioning

confidence: 99%

Health-Related Behaviors and Psychological Status of Adolescent Patients with Atopic Dermatitis: The 2019 Korea Youth Risk Behavior Web-Based Survey

Park¹,

Prochnow²,

Kim³

2023

PPA

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Objective Atopic dermatitis (AD) is one of the common chronic diseases that occur in children and adolescents as a chronic relapsing pruritic inflammatory skin disease. This study investigated how AD is associated with stress and depressive symptoms in a large representative sample of adolescents in South Korea. Methods The Korea Youth Risk Behavior Web-based Survey 2019 was used in this study (n = 57,069, weighted national estimates = 2,672,170). Multivariate logistic regression was used to determine significant associations between AD and mental health, measured by stress and depressive symptoms. Sub-group analysis was also conducted using various socio-economic variables. Results Among the present sample, 6.5% of adolescents (n = 173,909) were diagnosed with AD in the past 12 months. After adjusting for other variables, AD diagnosis was associated with significantly higher odds of experiencing stress (OR = 1.43) and depressive symptoms (OR = 1.32) as compared to adolescents without AD. A similar trend is found in subgroup model analysis using socio-economic variables (ie, education levels, parent’s income levels, and residence area). Specifically, female adolescents with AD, adolescents of low socio-economic status, those reporting smoking and drinking experience, and who do not participate in regular physical activity are more vulnerable to stress and depressive symptoms. Conclusion This is a noteworthy finding because it denotes that AD may lead to negative outcomes, like depressive symptoms or stress, which could be prevented if suspected early.

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General and Skin-Specific Health-Related Quality of Life in Patients With Atopic Dermatitis Before and During the COVID-19 Pandemic

Cited by 16 publications

References 76 publications

Impact of atopic dermatitis on quality of life: a large web-based survey from Argentina

Impact of atopic dermatitis on quality of life: a large web-based survey from Argentina

Cost-of-illness of adult atopic dermatitis from a societal perspective in Hungary

Health-Related Behaviors and Psychological Status of Adolescent Patients with Atopic Dermatitis: The 2019 Korea Youth Risk Behavior Web-Based Survey

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