Background This meta-analysis aimed to compare the potential effects of
local anesthesia (LA) and general anesthesia (GA) for transcather aortic
value implantation (TAVI). Measurements All relevant studies were
searched from the Pubmed, EMbase, Web of Science and the Cochrane
Library (January 1, 2016 to June 1, 2021). The main outcomes of this
literature meta-analysis were 30-day mortality, procedural time, new
pacemaker implantation, total stay in hospital, the use of vasoactive
drug, intra-and postoperative complications and emergencies, including
conversion to open, myocardial infraction, pulmonary complication,
vascular complication, renal injury/failure, stroke, transesophageal
echocardiography, life-threatening/major bleeding, cardiac tamponade,
emergency PCI. Pooled risk ratio (RR) and mean difference (MD) together
with 95% confidence interval (CI) were calculated. Results A total of
seventeen studies including 20938 patients in the final analysis
fulfilled the inclusion criteria. Intra-and postoperative complications
(myocardial infraction, vascular complication, renal injury/failure,
stoke, cardiac tamponade) undergoing TAVI in serious AS patients under
GA do not offer significant difference compared with LA. No differences
are observed between LA and GA for new pacemaker implantation, total
stay in hospital, transesophageal echocardiography, emergency PCI. GA is
associated with more adverse events, like the more overall mortality (RR
0.69, p=0.600), pulmonary complications (RR 0.54, p=0.278),
life-threatening/major bleeding (RR 0.85, p=0.855), the more times of
coversion to open (RR 0.22, p=0.746). LA has many advantages, including
a shorter procedure duration (MD=-0.38, p=0.000) and a reduction of the
use of vasoactive drug (RR 0.57,P=0.000). Conclusions For TAVI, both LA
with or without sedation and GA are feasible and safe. LA appears a
feasible alternative to GA for AS patients undergo TAVI.