General anesthetics activate a potent central pain-suppression circuit in the amygdala

Hua, Thuy; Chen, Bin; Lu, Dongye; Sakurai, K.; Zhao, Shengli; Han, Bao-Xia; Kim, Jiwoo; Yin, Luping; Chen, Yong; Lu, Jinghao; Wang, Fan

doi:10.1038/s41593-020-0632-8

Cited by 124 publications

(113 citation statements)

References 54 publications

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“…In addition, ketamine is able to produce rapid antidepressant responses by inducing prefrontal cortex synaptogenesis and reversing the synaptic deficits caused by chronic stress [ 96 ]. A recent study has shown that ketamine is capable of activating GABAergic neurons in the central amygdala in both acute and chronic pain states [ 97 ]. Other regions such as the insular cortex, periaqueductal gray, and nucleus accumbens may also be involved in the anti-aversive effects of ketamine.…”

Section: Discussionmentioning

confidence: 99%

Ketamine normalizes high-gamma power in the anterior cingulate cortex in a rat chronic pain model

et al. 2020

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Chronic pain alters cortical and subcortical plasticity, causing enhanced sensory and affective responses to peripheral nociceptive inputs. Previous studies have shown that ketamine had the potential to inhibit abnormally amplified affective responses of single neurons by suppressing hyperactivity in the anterior cingulate cortex (ACC). However, the mechanism of this enduring effect has yet to be understood at the network level. In this study, we recorded local field potentials from the ACC of freely moving rats. Animals were injected with complete Freund’s adjuvant (CFA) to induce persistent inflammatory pain. Mechanical stimulations were administered to the hind paw before and after CFA administration. We found a significant increase in the high-gamma band (60–100 Hz) power in response to evoked pain after CFA treatment. Ketamine, however, reduced the high-gamma band power in response to evoked pain in CFA-treated rats. In addition, ketamine had a sustained effect on the high-gamma band power lasting up to five days after a single dose administration. These results demonstrate that ketamine has the potential to alter maladaptive neural responses in the ACC induced by chronic pain.

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Section: Discussionmentioning

confidence: 99%

Ketamine normalizes high-gamma power in the anterior cingulate cortex in a rat chronic pain model

et al. 2020

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“…Of these sub‐regions, the central nucleus of the amygdala has been identified as a key component in pain processing (Allen et al., 2020; Simons et al., 2014). Recent findings from rodents indicate the central nucleus serves a dual or bidirectional role with cells mediating inhibitory functions and others serving a facilitating function (Hua et al., 2020; Neugebauer et al., 2020; Wilson et al., 2019).…”

Section: Discussionmentioning

confidence: 99%

Resilience, pain, and the brain: Relationships differ by sociodemographics

Tanner

Johnson

Terry

et al. 2021

J of Neuroscience Research

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Chronic musculoskeletal (MSK) pain is disabling to individuals and burdensome to society. A relationship between telomere length and resilience was reported in individuals with consideration for chronic pain intensity. While chronic pain associates with brain changes, little is known regarding the neurobiological interface of resilience. In a group of individuals with chronic MSK pain, we examined the relationships between a previously investigated resilience index, clinical pain and functioning measures, and pain-related brain structures, with consideration for sex and ethnicity/race. A cross-sectional analysis of 166 non-Hispanic Black and non-Hispanic White adults, 45-85 years of age with pain ≥ 1 body site (s) over the past 3 months was completed. Measures of clinical pain and functioning, biobehavioral and psychosocial resilience, and structural MRI were completed. Our findings indicate higher levels of resilience associate with lower levels of clinical pain and functional limitations. Significant associations between resilience, ethnicity/race, and/or sex, and pain-related brain gray matter structure were demonstrated in the right amygdaloid complex, bilateral thalamus, and postcentral gyrus. Our findings provide compelling evidence that in order to decipher the neurobiological code of chronic pain and related protective factors, it

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“…CeA PKCδ neurons and attenuate (rather than promote) pain-related behavior (Hua et al, 2020). CeA Sst neurons are also a good example of a "general encoding" population, since these neurons relate to appetitive stimuli (Kim et al, 2017;Wilson et al, 2019), but also contribute to the generation of defensive behaviors (Li et al, 2013;Penzo et al, 2015;Yu et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Encoding of environmental cues in central amygdala neurons during foraging

Ponserre

Fermani

Klein

2020

Preprint

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In order to successfully forage in an environment filled with rewards and threats, animals need to rely on familiar structures of their environment that signal food availability. The central amygdala (CeA) is known to mediate a panoply of consummatory and defensive behaviors, yet how specific activity patterns within CeA subpopulations guide optimal choices is incompletely understood. In a paradigm of appetitive conditioning in which mice freely forage for food across a continuum of cues, we find that two major subpopulations of CeA neurons, Somatostatin-positive (CeASst) and protein kinase Cδ-positive (CeAPKCδ) neurons can assign motivational properties to environmental cues and encode memory of goal location. While the proportion of food responsive cells was higher within CeASst than CeAPKCδ neurons, only the activities of CeAPKCδ, but not CeASst, neurons were required for learning of contextual food cues. Since CeAPKCδ neurons are known to promote a range of defensive behaviors, our findings point to a model in which CeA circuit components are not organized in specialized functional units but can process both aversive and rewarding information in a context and experience dependent manner.

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General anesthetics activate a potent central pain-suppression circuit in the amygdala

Cited by 124 publications

References 54 publications

Ketamine normalizes high-gamma power in the anterior cingulate cortex in a rat chronic pain model

Ketamine normalizes high-gamma power in the anterior cingulate cortex in a rat chronic pain model

Resilience, pain, and the brain: Relationships differ by sociodemographics

Encoding of environmental cues in central amygdala neurons during foraging

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