General concepts in biostatistics and clinical epidemiology: Experimental studies with randomized clinical trial design

Estrada, Sebastian; Arancibia, Marcelo; Stojanova, Jana; Papuzinski, Cristian

doi:10.5867/medwave.2020.02.7869

Cited by 9 publications

(8 citation statements)

References 74 publications

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“…Eight studies (34%) were categorized as low quality. As is clear, randomized clinical trials are the best method for controlling selection and confounding biases [ 50 , 51 ]. Quasi-experimental designs, due to the lack of random allocation, cannot express the effect of an intervention as clearly as experimental studies [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

The impact of health education interventions on oral health promotion among older people: a systematic review

Bashirian,

Khoshravesh,

Ayubi

et al. 2023

BMC Geriatr

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Background One of the most common pathologic changes in older people is oral and dental problems. The oral health of older people is a public health concern. Promotion of good oral health for this cohort will have beneficial impacts on the longer-term quality of life. This study aimed to identify the types of health education interventions for the oral health of older people and to determine their effects on the oral and dental health of older people. Methods Potential articles were retrieved from four electronic databases (PubMed/Medline, Scopus, Web of Sciences, and Embase) up to 31 September 2022 in English without limit of time. Experimental and quasi-experimental interventional studies investigating the impact of educational interventions on oral and dental health among older people over 60 years old in both sexes were considered. The quality assessment tool was the Effective Public Health Practice Project (EPHPP). Results In the initial search, 1104 articles were retrieved. Finally, according to the inclusion criteria, 23 studies (seventeen randomized controlled trials (RCT) and six quasi-experimental studies) were reviewed. In this review, educational interventions for older people and their caregivers are classified. Theoretical frameworks were used in only three interventions related to older people. Outcome measures were both self-reported and objective measures. Fifteen of the included studies were of moderate quality. Conclusion This review provides evidence that the use of oral and dental health educational interventions was effective in improving the oral health of older people. Educational interventions were carried out both among older people and among their caregivers. Although a variety of interventions were used in the reviewed studies, more lectures were used in the interventions related to older people. In the interventions related to caregivers, in addition to lectures, practical education was also used. It is recommended to perform higher quality studies for assessing the effectiveness of interventions in this field.

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Section: Discussionmentioning

confidence: 99%

The impact of health education interventions on oral health promotion among older people: a systematic review

Bashirian,

Khoshravesh,

Ayubi

et al. 2023

BMC Geriatr

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“…The results of this study show that most of the included studies adopted RCT designs (60%), and the rest were cohort studies. Randomized clinical trials are the best way to control selection and confounding bias [ 55 ]. Therefore, it is necessary to carry out more high-quality randomized clinical trials in future continuing nursing studies after lower limb joint replacement in older patients.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of continuous nursing in improving functional recovery after total hip or knee arthroplasty in older adults: A systematic review

Sun,

Xu,

Zhu

et al. 2024

International Journal of Nursing Sciences

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“…In long-term studies that establish different treatments, it is important that blinding be incorporated into the study design to minimize investigator influences on the results and thus obtain valid results, clearer interpretations and highly reliability studies. 29 Because of that, a double-blind study was chosen, in which the patient and the statistician will be blinded. This blinding will be important because it will ensure parents/guardians provide the same care on both sides of the mouth during their child's oral hygiene.…”

Section: Discussionmentioning

confidence: 99%

Can bulk-fill resin restorations be an alternative to resin-modified glass ionomer cement restorations in primary molars of toddlers? A randomized clinical trial protocol.

Novaes¹,

Clementino²,

Ferreira³

et al. 2021

J Oral Res

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Background: The aim of this study was to elaborate a randomized clinical trial protocol to evaluate the effectiveness of class I restorations in resin-modified glass ionomer cement (RMGIC) and bulk-fill resin in primary molars with untreated early childhood caries in toddlers. Material and Methods: A total of 59 toddlers up to 36 months old with at least two primary molar teeth with untreated dental caries of single surface on different sides of the mouth will be selected at the Pediatric Dentistry Clinics of the Faculty of Dentistry at Federal University of Minas Gerais (UFMG), Brazil. Teeth with untreated dental caries in the left and right sides of each patient’s mouth will be randomly distributed into 2 groups: Group 1 (Control): encapsulated RMGIC restoration with Riva light cure (SDI, Florida, USA) and Group 2 (Test): Filtek bulk-fill composite resin restoration (3M/ESPE, St. Paul, USA) with universal single bond adhesive system (3M/ESPE, St. Paul, USA). A single trained dentist will perform all restorative procedures. The restorations will be evaluated after 1, 6, 12, 18 and 24 months by two trained and calibrated examiners. Cost-efficacy analysis will be carried out. Kaplan-Meier survival analysis, Log-rank test, Cox regression, Poisson regression analysis, Mann-Whitney test or Kruskal-Wallis will be performed to analyze data. Conclusion: The protocol will make it possible to determine the most efficacy material for the restoration of cavities in cavities in primary molars of toddlers.

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General concepts in biostatistics and clinical epidemiology: Experimental studies with randomized clinical trial design

Cited by 9 publications

References 74 publications

The impact of health education interventions on oral health promotion among older people: a systematic review

The impact of health education interventions on oral health promotion among older people: a systematic review

Efficacy and safety of continuous nursing in improving functional recovery after total hip or knee arthroplasty in older adults: A systematic review

Can bulk-fill resin restorations be an alternative to resin-modified glass ionomer cement restorations in primary molars of toddlers? A randomized clinical trial protocol.

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