The Loop Current (LC) in the Gulf of Mexico (GoM) is part of the western North Atlantic circulation. Recording its strength and slowdown variations can help us characterize the regional climate over the Late Pleistocene. To reconstruct the sea surface and the LC intensity in the eastern GoM, we study the distribution patterns of planktonic foraminifera in the core EN-032-18PC, spanning the end of Marine Isotope Stage (MIS) 9 to early MIS-4. We reconstructed a sequence of paleoceanographic events based on stable isotopes ( 18 O and 13 C) of the surface dweller Globigerinoides ruber and two faunal assemblages. The first assemblage explains most of the glacial and late interglacial periods, suggesting a subtropical environment with a deep thermocline and a reduced LC due to a moderate inflow of warm Caribbean waters. The second assemblage explains the warmest interglacial substages, dominated by tropical species, a shallow thermocline, and an extended LC, driven by summer insolation. Overall, surface ocean conditions led to more ecological successions and instability during the warmest interglacial substages than during glacial periods, as supported by the stable isotope records. Besides the GoM relationship to AMOC, as a regulator of heat transport to higher latitudes, we suggest that fluctuations in the LC rely on the migration of atmospheric circulation patterns and astronomical insolation forcing.