General Gamma Correction Pinhole Bone Scan Diagnosis

Bahk, Yong‐Whee

doi:10.1007/978-981-10-2759-8_24

Cited by 1 publication

(2 citation statements)

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“…Recent developments in GCPBS have made it necessary to devise a quantitative method for assessing 99m Tc-HDP uptake to allow the precise morphobiochemical evaluation of BME, BMH, and TMF. 2,3,8 We therefore designed the VSMA to specifically visualize, distinguish, and quantitate BME, BMH, and TMF using sequential nPBS and GCPBS, NIH ImageJ densitometry, and pixelized measurement. TMF, BME, and BMF are fundamental histopathological changes that occur ubiquitously in cases of trauma, sports injury, osteoporosis, inflammation, infection, neoplasms, and other bone diseases, as well as during daily physiological activities.…”

Section: Discussionmentioning

confidence: 99%

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Precise differential diagnosis of acute bone marrow edema and hemorrhage and trabecular microfractures using naïve and gamma correction pinhole bone scans

et al. 2019

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Objective To analyze the performance of sequential naïve pinhole bone scan (nPBS) and gamma correction pinhole bone scan (GCPBS), reinforced by ImageJ densitometry and pixelized microfracture measurement, for making specific diagnoses of bone marrow edema (BME), bone marrow hemorrhage (BMH), and trabecular microfractures (TMF). Methods We prospectively examined BME, BMH, TMF, and normal trabeculae in 10 patients using sequential nPBS and GCPBS. The intensity of 99mtechnetium-hydroxydiphosphonate (99mTc-HDP) uptake was measured using a pixelized method and calculated using ImageJ densitometry in terms of arbitrary units (AU). This overall method was termed a visuospatial-mathematic assay (VSMA). We analyzed the ability of the calculated AU values to discriminate between the four states using GraphPad Prism software, with reference to previous morphological data. Results The calculated values were categorized as ≤50 AU for normal trabecula, 51–100 AU for BME, 101–150 AU for BMH, and ≥151 AU for TMF. The difference in uptake between normal trabecula and BME was significant and the differences among BME, BMH, and TMF were highly significant. Conclusion VSMA is a useful technique for refining objective individual diagnoses and for differentiating and quantitating BME, BMH, and TMF.

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Section: Discussionmentioning

confidence: 99%

“…The increased 99m Tc-HDP uptake in acute TMF has been demonstrated radiobiochemically and scintigraphically to be due to the avid biochemical incorporation of bone tracer into amorphous calcium phosphate in the injured bone, while the suppressed uptake in BME and BMH is ascribed to 99m Tc-HDP adhesion to crystalline hydroxyapatite. 2,8,12…”

Section: Discussionmentioning

confidence: 99%