General Lectures-(II)

Summary The prevalence of atopy (assessed by prick testing and serum IgE measurement), and of symptoms associated with atopy, has been defined in 122 patients with inflammatory bowel disease (IBD) and 103 age‐matched controls. History analysis for atopic symptoms, and serum IgE levels, showed no differences between controls and IBD patients, or IBD subgroups (Crohn's disease, ulcerative colitis, ulcerative proctitis). Both in controls and in IBD patients, the prevalence of positive skin tests was higher in young people (aged > 30) than in others; taking account of age distribution within the groups, there were no differences between controls and IBD patients, or subgroups, in the prevalence of positive skin tests. Our findings do not support the hypothesis that reaginic hypersensitivity plays a significant role in the pathogenesis of IBD.

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Atopy in Inflammatory Bowel Disease

Mee

Brown

Jewell

1979

Scandinavian Journal of Gastroenterology

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Thirty-nine patients with ulcerative colitis and 35 with Crohn's disease have been investigated for evidence of reaginic hypersensitivity and compared with control subjects. There was no difference in the frequency of a personal or family history of atopy or in serum IgE levels. Similarly, no overall difference was noted in prick test responses to 21 allergens. However, further analysis of prick test responses showed that patients with inflammatory bowel disease responded more frequently to food allergens. This was highly significant when compared with healthy controls (p less than 0.001). The relevance of this finding to the aetiology of inflammatory bowel disease is discussed.

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General Lectures-(II)

Cited by 3 publications

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Immunophänomene bei chronisch entzündlichen Darmerkrankungen

Immunophänomene bei chronisch entzündlichen Darmerkrankungen

Prevalence of atopy is unrelated to presence of inflammatory bowel disease

Atopy in Inflammatory Bowel Disease

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