General medical conditions in 347 bipolar disorder patients: Clinical correlates of metabolic and autoimmune-allergic diseases

Perugi, Giulio; Quaranta, G.; Belletti, S; Casalini, Francesca; Mosti, N; Toni, Cristina; Dell’Osso, Liliana

doi:10.1016/j.jad.2014.08.052

Cited by 85 publications

(55 citation statements)

References 87 publications

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“…This patient also suffered from psoriasis vulgaris; therefore, an autoinflammatory predisposition seems to be plausible. Such associations with autoimmune diseases have been described previously (30). One might speculate that the bipolar symptoms and the thyroid and skin disease are different signs of immune dysregulation in this patient.…”

Section: Discussionsupporting

confidence: 79%

Alterations in Cerebrospinal Fluid in Patients with Bipolar Syndromes

et al. 2016

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Bipolar disorder (BD) is a severe and lifelong condition. Primary endogenic polygenetic forms are common. Secondary organic forms have received increasing interest recently due to the detection of immunological encephalopathies that mimic various psychiatric syndromes, including BD. However, only limited data about routine findings of cerebrospinal fluid (CSF) analyses in BD are available. Therefore, we investigated the frequency of alterations in the CSF in patients with BD and the association with autoantibodies, cerebral magnetic resonance imaging, and electroencephalography findings. CSF samples of patients with BD collected from January 1998 until December 2015 were analyzed retrospectively. Patients with preexisting causes for alterations in the CSF (e.g., patients with obvious past or current neurological disorders) were excluded. In total, 63 patients with BD fulfilled the inclusion criteria for the study. In 1.6% of the patients with BD, an increased white blood cell count was found in the CSF. Increased albumin quotients were found in 12.9% of the patients, oligoclonal bands (OCBs) in 1.6%, and increased immunoglobulin (Ig) G indices in 3.2% (OCBs were not measured in case of increased IgG indices). No significant differences in CSF findings were found between patients with manic and depressive episodes. The main findings of this open uncontrolled study are that alterations in the CSF may be found in a small, but potentially relevant, subgroup of patients with BD. These findings are discussed in light of the new concepts of mild encephalitis and immunological encephalopathy. The detection of patients with possibly secondary organic bipolar syndromes could open up new causal treatment options with immunomodulatory medication.

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Section: Discussionsupporting

confidence: 79%

Alterations in Cerebrospinal Fluid in Patients with Bipolar Syndromes

et al. 2016

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“…Eleven articles and 1 trial were screened for eligibility, of which 1 did not have a control group, [19] 1 did not focus on BD patients, [20] 2 were review articles, [21,22] and 1 was a case report. [23] The trial of NCT02657668 in the ClinicalTrials.gov was excluded because of lack of results of the study.…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis and systematic review of the comorbidity between irritable bowel syndrome and bipolar disorder

Tseng¹,

Zeng²,

Chen

et al. 2016

Medicine

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“…Thirteen articles were initially eligible, but one did not have a control group 25 and one contained not simply BD patients. 26 Of the remaining 11 articles, 2 were conducted by the same research team and their clinical data were the same.…”

Section: Resultsmentioning

confidence: 99%

Significantly Higher Prevalence Rate of Asthma and Bipolar Disorder Co-Morbidity

Wang

Chen

et al. 2016

Medicine

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Asthma and bipolar disorder (BD) are 2 distinct diseases that share similar pathophysiology. This study aimed to determine their relationship thorough a meta-analysis of articles on their comorbidity rate.The aim of the study is to examine the overall prevalence rate of BD in asthmatic patients and of asthma in BD patients compared to healthy controls.Electronic research of PubMed and ClinicalTrials.gov was performed.Articles discussing the prevalence rate of BD in patients with/without asthma and the prevalence rate of asthma in those with/without BD, as well as clinical trials in humans and case-controlled trials or cohort studies, were all included. Case reports or series and nonclinical trials were excluded.Through a random-effects model, a meta-analysis of the results of 4 studies comparing the prevalence rate of BD in patients with/without asthma, and in 6 studies comparing the prevalence rate of asthma in subjects with/without BD were performed.There were significantly higher prevalence rates of BD in asthmatic patients than in healthy controls (P < .001) and of asthma in BD patients than in healthy controls (P < .001). Only the patient's mean age significantly modulated the odds ratio of the prevalence rate of asthma in BD patients (slope = 0.015, P < .001).Only 10 studies were included and most were cross-sectional studies. The possible confounding effect of medication on BD or asthma onset was not investigated. Any possible etiology of the comorbidity was also not determined.This meta-analysis highlights the importance of the significantly high comorbid rate of BD and asthma, and the positive association with age. Special attention must be given to the comorbidity of asthma and BD, especially in older patients.

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General medical conditions in 347 bipolar disorder patients: Clinical correlates of metabolic and autoimmune-allergic diseases

Cited by 85 publications

References 87 publications

Alterations in Cerebrospinal Fluid in Patients with Bipolar Syndromes

Alterations in Cerebrospinal Fluid in Patients with Bipolar Syndromes

A meta-analysis and systematic review of the comorbidity between irritable bowel syndrome and bipolar disorder

Significantly Higher Prevalence Rate of Asthma and Bipolar Disorder Co-Morbidity

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