We discuss a set of novel discrete symmetry transformations of the N = 4 supersymmetric quantum mechanical model of a charged particle moving on a sphere in the background of Dirac magnetic monopole. The usual five continuous symmetries (and their conserved Noether charges) and two discrete symmetries together provide the physical realizations of the de Rham cohomological operators of differential geometry. We have also exploited the supervariable approach to derive the nilpotent N = 4 SUSY transformations and provided the geometrical interpretation in the language of translational generators along the Grassmannian directions θ α andθ α onto (1, 4)-dimensional supermanifold.PACS numbers: 11.30.Pb, 03.65.-w, 02.40.-k Keywords: N = 4 SUSY QM algebra; continuous and discrete symmetries; de Rham cohomological operators; Hodge theory; supervariable approach; nilpotency property * On a compact manifold without a boundary, mathematically, there exits three differential operators (d, δ, ∆) which are called cohomological operators of differential geometry. These three de Rham cohomological operators obey the following algebra: d 2 = δ 2 = 0, ∆ = (d + δ) 2 = {d, δ}, [∆, d] = [∆, δ] = 0 where (δ)d are the (co-)exterior derivatives and ∆ is the Laplacian operator. The exterior and co-exterior derivatives together satisfy an interesting relationship: d = ± * δ * where * is the Hodge duality operation.