General Morphological Characteristics of the Results of Experimental Modeling of Aseptic Peritonitis

Hryn, Volodymyr; Kostylenko, Yuriy; Maksymenko, Oleksandr

doi:10.1016/j.aanat.2023.152160

Cited by 5 publications

(1 citation statement)

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“…Currently, the diverse experimental models of peritonitis exist, and all of them have their advantages and disadvantages. The common models of peritonitis can be the methods of introduction of foreign bodies (Hryn et al, 2023a) or chemicals into the abdominal cavity, or bacterial contamination of the abdominal cavity with cultures of pathogenic microorganisms, or by opening the lumen of the colon or combination of both methods (Fantin et al, 2019;Montenegro et al, 2020;Vintrych et al, 2022). At the same time, thickening of the adipose tissue of the omentum, which, thereby, isolates the peritoneal cavity from the foci of inflammation was noted.…”

Section: Discussionmentioning

confidence: 99%

Morphological Characteristics of the Results of Experimental Modeling of Septic Peritonitis

Hryn,

Maksymenko

2024

Int. J. Morphol.

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Experimental studies devoted to the study of the mechanisms of the pathogenesis of acute peritonitis and the development of new methods of medical and surgical treatment are becoming increasingly relevant. Today, experimental medicine knows many different ways to modeling septic peritonitis and eliminate it, but the role of the local immune system is underestimated, whereas it takes a direct part in inflammation. The objective of our work to study morphological features of results of experimental modeling of septic peritonitis in white rats. The study included 15 sexually mature white male rats weighing 276.75±6.56 grams. A simulation of septic peritonitis was performed by perforating the upper part of the cecum with four punctures with a G16 injection needle. As a result of the experiment, after examination of the peritoneal cavity, all 15 animals were diagnosed with omentum tamponade of perforated damage to the caecum. In 11 cases, the perforated wall of the caecum was covered by the greater omentum (73.34 %), and in the other 4 animals, tamponade was performed by one of the epididymal omentum (26.66 %). The initial stage of tamponade with the greater or epididymal omentums of a perforated caecum begins on the first day of the experiment and consists of tight interstitial consolidation between them, as well as in the invasion of blood vessels from the omentum side to the focus of infection, which ensure the delivery of the appropriate immunocompetent cells. As a result of this process, intensive lymphoid infiltrates are formed in this area, as well as the growth of adipose tissue, which isolates the inflammatory focus from the peritoneal cavity with a thick layer.

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