General Motors Cancer Research Foundation prizes Charles F. Kettering prize. Acute leukemia in children. Model for the development of scientific methodology for clinical therapeutic research in cancer

Frei, Emil

doi:10.1002/1097-0142(19840515)53:10<2013::aid-cncr2820531003>3.0.co;2-2

Cited by 19 publications

(3 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prednisone or prednisolone are lympholytic and highly effective in the treatment of acute lymphoblastic leukemia (ALL). Some ALL patients achieved a short-lived remission when either ACTH or glucocorticoids were used [43]. The inadvertent prescription of monotherapy with glucocorticoids to a patient with acute leukemia may compromise their long-term outcome and is not consistent with the current standard of care for these patients.…”

Section: What Is the Role Of The Marrow Examination?mentioning

confidence: 99%

Controversies in the diagnosis and management of childhood acute immune thrombocytopenic purpura

Segel¹,

Feig²

2009

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Acute immune thrombocytopenic purpura (ITP) occurs most commonly in young children who present with severe isolated thrombocytopenia and purpura. A marrow examination is not required unless glucocorticoids are used, lest treatment mask incipient acute lymphoblastic leukemia, but controversy exists here. The recommendations for evaluation and management remain controversial, since prospective controlled trials have not been done. There is some consensus based on experience and empiric data. Almost all children with acute ITP will recover completely without therapy. Although the various treatments may increase the platelet count, they do not influence the outcome of the illness, may increase cost, and cause significant side effects. Therefore, careful observation may be the best management option for the patient with ITP, in the absence of severe bleeding. The data available relevant to these issues are discussed.

show abstract

Section: What Is the Role Of The Marrow Examination?mentioning

confidence: 99%

Controversies in the diagnosis and management of childhood acute immune thrombocytopenic purpura

Segel¹,

Feig²

2009

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…Combination chemotherapy was initially studied in childhood ALL and many of the principles of modern day chemotherapy derive from these initial studies [45]. The first trials of combination chemotherapy in lymphoma date back to the 1970s [46].…”

Section: Chemotherapymentioning

confidence: 99%

Follicular lymphoma: a historical overview

Besien

Schouten

2007

Leukemia & Lymphoma

View full text Add to dashboard Cite

Lymphoma was first described in 1862 and follicular lymphoma in 1925. Initially considered a benign disorder, and named Brill - Symmers disease after the authors of the original papers, it was rapidly recognized as a malignancy with a variable but often indolent course. Most of its clinical features were described by the early 1940s. Despite discussion about its cell of origin, and in contrast to many other lymphoma subtypes, follicular lymphoma could always be accurately recognized and diagnosed using light microscopy morphological features. B-cell origin was demonstrated in the 1970s and the important role of t(14;18) and bcl-2 gene rearrangement in the pathogenesis of follicular lymphoma was established shortly thereafter. The etiology of follicular lymphoma, the reason for marked geographic variation in its incidence, the role of alternative molecular pathways in its pathogenesis, and the cause for its variable clinical behavior all remain unknown. Several observations suggest an important role for the normal immune response in regulating the clinical behavior of follicular lymphoma. From the earliest descriptions, radiation therapy was shown to be very effective in follicular lymphoma, but not curative. Combination chemotherapy was tested in the 1970s, but despite high rates of response, there was only minimal impact on survival. Interferon combined with anthracycline based chemotherapy was the first treatment to improve survival, but was not widely adopted in the USA. Randomized studies have shown an impact of autologous transplantation on progression free survival. Allogeneic transplantation is a curative therapy, but is too toxic for widespread application. Targeted therapies, particularly rituximab have revolutionized the treatment of follicular lymphoma. A convergence of technological and biological advances will likely lead to further dramatic progress in the next decade. For the first time consistent improvements in survival of follicular lymphoma are reported.

show abstract

“…The rationale behind this is simple: there are many classes of anti-cancer drugs and combining drugs from different classes will lead to differing and non-overlapping mechanisms of cell toxicity or cytostasis and reduced likelihood of cancer cell resistance (1). Rationales for combination chemotherapy include the potential for sequential or concurrent attack on biochemical or cellsignaling pathways, manipulation of drug transport or drug metabolism systems, use of metabolites to preferentially rescue normal cells from anti-metabolite effects, metabolic modulation, and approaches involving cell synchronization and recruitment (2,3). Finally, these combinations may be utilized without reduction in the maximum tolerated dose levels employed, and in some cases may even allow for dose reduction without a resultant loss in efficacy.…”

Section: Introductionmentioning

confidence: 99%

Trastuzumab and Liposomal Doxorubicin in the Treatment of MCF-7 Xenograft Tumor-Bearing Mice: Combination Does Not Affect Drug Serum Levels

Waterhouse¹,

Denyssevych²,

Hudon³

et al. 2005

Pharm Res

View full text Add to dashboard Cite

show abstract

General Motors Cancer Research Foundation prizes Charles F. Kettering prize. Acute leukemia in children. Model for the development of scientific methodology for clinical therapeutic research in cancer

Cited by 19 publications

References 55 publications

Controversies in the diagnosis and management of childhood acute immune thrombocytopenic purpura

Controversies in the diagnosis and management of childhood acute immune thrombocytopenic purpura

Follicular lymphoma: a historical overview

Trastuzumab and Liposomal Doxorubicin in the Treatment of MCF-7 Xenograft Tumor-Bearing Mice: Combination Does Not Affect Drug Serum Levels

Contact Info

Product

Resources

About