The Alternating Direction Method of Multipliers (ADMM) has been proved to be effective for solving separable convex optimization subject to linear constraints. In this paper, we propose a Generalized Symmetric ADMM (GS-ADMM), which updates the Lagrange multiplier twice with suitable stepsizes, to solve the multi-block separable convex programming. This GS-ADMM partitions the data into two group variables so that one group consists of p block variables while the other has q block variables, where p ≥ 1 and q ≥ 1 are two integers. The two grouped variables are updated in a Gauss-Seidel scheme, while the variables within each group are updated in a Jacobi scheme, which would make it very attractive for a big data setting. By adding proper proximal terms to the subproblems, we specify the domain of the stepsizes to guarantee that GS-ADMM is globally convergent with a worst-case O(1/t) ergodic convergence rate. It turns out that our convergence domain of the stepsizes is significantly larger than other convergence domains in the literature. Hence, the GS-ADMM is more flexible and attractive on choosing and using larger stepsizes of the dual variable. Besides, two special cases of GS-ADMM, which allows using zero penalty terms, are also discussed and analyzed. Compared with several state-of-the-art methods, preliminary numerical experiments on solving a sparse matrix minimization problem in the statistical learning show that our proposed method is effective and promising.is the Lagrangian function of the problem (1) with the Lagrange multiplier λ ∈ R n . Then, the ALM procedure for solving (1) can be described as follows:However, ALM does not make full use of the separable structure of the objective function of (1) and hence, could not take advantage of the special properties of the component objective