General Practitioners' Use of Non-Steroidal Anti-Inflammatory Drugs in Tayside and Fife Regions

Keys, John D.; Beardon, P. H. G.; Lau, CS; Lang, Claudio; McDevitt, DG

doi:10.1177/014107689208500806

Cited by 22 publications

(1 citation statement)

References 16 publications

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“…Two additional model drugs that belong to anti-inflammatory and analgesic drugs, FFA and MFA, were selected. Both of them were among the top nonsteroidal anti-inflammatory drugs (NSAIDs) prescribed in the 1990s . During the last decade, these drugs have been used for the analgesic treatment of rheumatoid arthritis, migraine, and, especially, primary dysmenorrhea in worldwide. , In addition, MFA was also proven to be a synergistic effect with ionizing radiation in colon cancer .…”

Section: Resultsmentioning

confidence: 99%

Highly Efficient Production of Desired Solid Forms of Drugs with Improved Mechanical Properties via an Organic Solvent-Free Sublimation Process

Zhao

Liu

et al. 2023

ACS Sustainable Chem. Eng.

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The pharmaceutical industry is required to constantly broaden its development areas and accelerate technical transformation because of the continued global rise in medicine consumption. However, the usage of organic solvents in pharmaceutical production results in up to 20 million tons annually of chemical waste, causing a serious environmental problem. Here, we proposed a solvent-free sustainable chemical technology, sublimation crystallization, for highly efficient screening and preparation of pharmaceutical solid forms (i.e., polymorphs), which eliminates the wastes associated with solvent use from the source. By adjusting the parameters of sublimation crystallization, we have obtained multiple polymorphs of several important drugs, including the antituberculosis drug pyrazinamide (PZA) and nonsteroidal anti-inflammatory drugs (NSAIDs), flufenamic acid (FFA) and mefenamic acid, particularly γ form of PZA and polymorphs IV and VII of FFA, which are difficult to produce from conventional solution crystallization methods. Mechanical property measurements from both powder and single crystal tests reveal that the γ form of PZA readily prepared by sublimation crystallization has the most excellent tabletability properties. In situ crystal growth observations indicate a direct vapor-to-crystal growth mechanism for the sublimation crystallization process consistent with conventional vapor phase deposition. Furthermore, the governing factors and growth mechanisms of sublimation and solution crystallization processes were analyzed and discussed, and it was found that the rate-limiting step of crystal growth is the surface-integration process in solution crystallization, whereas it becomes the surface diffusion process in sublimation crystallization. Overall, our developed sublimation crystallization provides a promising green technology for the development and production of (new) drugs, broadening the thinking behind the development of sustainable chemicals.

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