General synthesis of primary amines via reductive amination employing a reusable nickel catalyst

Selective Transformations of Triglycerides into Fatty Amines, Amides, and Nitriles by using Heterogeneous Catalysis

“…It is noteworthy that the thus‐obtained fatty amines are an important class of chemicals for the industrial production of surfactants, germicides, and softeners. Although the reductive amination of relatively reactive carbonyl compounds such as ketones and aldehydes into amines has been studied extensively, reports on the reductive amination of carboxylic acids and esters including triglycerides remain relatively rare . Our heterogeneous catalytic system using NH 3 as a nitrogen source and H 2 does not require any additives and could thus serve as an effective method for the direct transformation of triglycerides into fatty amines.…”

Iron‐Catalysed Reductive Amination of Carbonyl Derivatives with ω‐Amino Fatty Acids to Access Cyclic Amines

“…Noticeably,i nt he absence of A under similar conditions with 2-4 equiv. of phenylsilane, no 3a was obtained;t he main product obtained was 4.A dditionally,i fF e(CO) 5 or Fe 3 (CO) 12 was used under our optimized conditions, even thoughf ull conversion was reached, benzyl alcohol resulting from the reduction of benzaldehyde was obtained as the major product (59a nd 99 %, respectively), showing the crucial role of the IMes ligand for the selectivity of the reaction. It must be also mentioned that this transformation with A under hydrogenation or hydrogen-transfer conditions did not succeed ( Table S2 in the Supporting Information).…”

“…[a] D. Wei tion reactions. [11] For the synthesis of amines, reductivea mination is one of moste fficient methodologies, [12] in particular with iron catalysts, which exhibit good activities. [13] Additionally,r eductiont hrough hydrosilylation is ap romising alternative for the selectivec atalytic transformationo fo rganic molecules compared with other reduction methodss uch as catalytic hydrogenation [14] and transfer hydrogenation reactions [15] or the stoichiometric reduction with metal hydrides (e.g.,a luminium and boron hydrides).…”

“…Notably,p iperidines bearing reducible functional groups such as carboxylic ester (3j)a nd amide (3k)w ere prepared in 62 and 78 %y ield, respectively,h ighlighting the good functional group tolerance of this transformation. The reactionw ith p-(acetyl)aniline led to al ess selectiver eaction; the piperidine 3l 100 0---4P MHS [ 12] 100 0---5 [b] PhSiH 3 [4] 100 98 67 31 0 6 [c] PhSiH 3 [4] 100 99 87 12 0 7P hSiH 3 [4] 80 97 47 50 0 8P hSiH 3 [4] 50 97 32 65 0 9P hSiH 3 [4] 30 96 72 56 4 (72 %y ield) waso btained in mixture with 20 %o ft he fully reduced product 1-[(p-piperidylmethyl)phenyl]ethan-1-ol. Additionally,h eteroaromatic aldehydes based on pyrrole, furan, thiophenea nd quinoline cores were effectively transformed into 3m-3 p in yields up to 97 %.…”

Challenges and Directions for Green Chemical Engineering—Role of Nanoscale Materials

“…Thanks to this property, several non-noble metal catalyzed processes have been developed 22,23 in order to reduce the consumption of exhaustive metals. In these endeavors, the careful design of the support and the final catalyst has been found to be crucial for the catalytic process, indeed for example, the acidbase properties of inorganic supports can affect the reactivity, or the support can be compromised by the reaction conditions, including temperature or pH.…”