Generalised muscle weakness in young adults with congenital heart disease

Greutmann, Matthias; Le, Thao; Tobler, Daniel; Biaggi, Patric; Oechslin, Erwin; Silversides, Candice; Granton, John

doi:10.1136/hrt.2010.213579

Cited by 112 publications

(83 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is evidence that adults with CHD are deconditioned as a result of inappropriate restriction from participation in physical activities. 36 -38 In fact, Greutmann et al 39 recently showed that the degree of respiratory and skeletal muscle weakness commonly present in adult CHD patients is comparable to that in patients with advanced heart failure in acquired heart disease. It is possible that patients with muscle weakness terminate CPX before the limits of the cardiovascular system are reached, which, in turn, would result in failure to achieve VT.…”

Section: Inuzuka Et Al Exercise Testing In Congenital Heart Diseasementioning

confidence: 99%

Comprehensive Use of Cardiopulmonary Exercise Testing Identifies Adults With Congenital Heart Disease at Increased Mortality Risk in the Medium Term

et al. 2012

View full text Add to dashboard Cite

Background-Parameters of cardiopulmonary exercise testing were recently identified as strong predictors of mortality in adults with congenital heart disease. We hypothesized that combinations of cardiopulmonary exercise testing parameters may provide optimal prognostic information on midterm survival in this population. Methods and Results-A total of 1375 consecutive adult patients with congenital heart disease (age, 33Ϯ13 years) underwent cardiopulmonary exercise testing at a single center over a period of 10 years. Peak oxygen consumption (peak V O 2 ), ventilation per unit of carbon dioxide production (V E/V CO 2 slope), and heart rate reserve were measured. During a median follow-up of 5.8 years, 117 patients died. Peak V O 2 , heart rate reserve, and V E/V CO 2 slope were related to midterm survival in adult patients with congenital heart disease. Risk of death increased with lower peak V O 2 and heart rate reserve. A higher V E/V CO 2 slope was also related to increased risk of death in noncyanotic patients, whereas the V E/V CO 2 slope was not predictive of mortality in cyanotic patients. The combination of peak V O 2 and heart rate reserve provided the greatest predictive information after adjustment for clinical parameters such as negative chronotropic agents, age, and presence of cyanosis. However, the incremental value of these exercise parameters was reduced in patients with peak respiratory exchange ratio Ͻ1.0. Conclusions-Cardiopulmonary exercise testing provides strong prognostic information in adult patients with congenital heart disease. Prognostication should be approached differently, depending on the presence of cyanosis, use of rate-lowering medications, and achieved level of exercise. We provide 5-year survival prospects based on cardiopulmonary exercise testing parameters in this growing population. (Circulation. 2012;125:250-259.)

show abstract

Section: Inuzuka Et Al Exercise Testing In Congenital Heart Diseasementioning

confidence: 99%

Comprehensive Use of Cardiopulmonary Exercise Testing Identifies Adults With Congenital Heart Disease at Increased Mortality Risk in the Medium Term

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Respiratory and skeletal muscle weakness was common in young adults with complex CHD and similar to that found in adults with advanced heart failure from acquired disease. 69 Intrinsic causes of restrictive lung disease include decreased pulmonary blood flow that may hinder growth and development of lung parenchyma, resulting in pulmonary hypoplasia. 70 This may partly explain the significantly higher prevalence of restrictive lung physiology in patients with TOF.…”

Section: Pathogenesismentioning

confidence: 99%

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Lui¹,

Saïdi²,

Bhatt³

et al. 2017

Circulation

180

136

View full text Add to dashboard Cite

ABSTRACT:Life expectancy and quality of life for those born with congenital heart disease (CHD) have greatly improved over the past 3 decades. While representing a great advance for these patients, who have been able to move from childhood to successful adult lives in increasing numbers, this development has resulted in an epidemiological shift and a generation of patients who are at risk of developing chronic multisystem disease in adulthood. Noncardiac complications significantly contribute to the morbidity and mortality of adults with CHD. Reduced survival has been documented in patients with CHD with renal dysfunction, restrictive lung disease, anemia, and cirrhosis. Furthermore, as this population ages, atherosclerotic cardiovascular disease and its risk factors are becoming increasingly prevalent. Disorders of psychosocial and cognitive development are key factors affecting the quality of life of these individuals. It is incumbent on physicians who care for patients with CHD to be mindful of the effects that disease of organs other than the heart may have on the well-being of adults with CHD. Further research is needed to understand how these noncardiac complications may affect the long-term outcome in these patients and what modifiable factors can be targeted for preventive intervention.

show abstract

“…Skeletal muscle atrophy and weakness accompany several pathophysiological conditions, including muscle disuse (D'Antona et al, 2003), aging (Gosselin et al, 1994;Larsson et al, 1997a;Larsson et al, 1997b;Lowe et al, 2001;Thompson and Brown, 1999), cancer (Roberts et al, 2013a;Roberts et al, 2013b) and chronic heart failure (Evans et al, 1995;Greutmann et al, 2011). The loss of skeletal muscle mass and impaired function during these conditions contribute to reduced physical performance and quality of life, prolonged hospital stays and enhanced mortality (Evans, 2010).…”

Section: Introductionmentioning

confidence: 99%

HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy

Beharry

Sandesara

Roberts

et al. 2014

Journal of Cell Science

103

116

View full text Add to dashboard Cite

The Forkhead box O (FoxO) transcription factors are activated, and necessary for the muscle atrophy, in several pathophysiological conditions, including muscle disuse and cancer cachexia. However, the mechanisms that lead to FoxO activation are not well defined. Recent data from our laboratory and others indicate that the activity of FoxO is repressed under basal conditions via reversible lysine acetylation, which becomes compromised during catabolic conditions. Therefore, we aimed to determine how histone deacetylase (HDAC) proteins contribute to activation of FoxO and induction of the muscle atrophy program. Through the use of various pharmacological inhibitors to block HDAC activity, we demonstrate that class I HDACs are key regulators of FoxO and the muscle-atrophy program during both nutrient deprivation and skeletal muscle disuse. Furthermore, we demonstrate, through the use of wild-type and dominant-negative HDAC1 expression plasmids, that HDAC1 is sufficient to activate FoxO and induce muscle fiber atrophy in vivo and is necessary for the atrophy of muscle fibers that is associated with muscle disuse. The ability of HDAC1 to cause muscle atrophy required its deacetylase activity and was linked to the induction of several atrophy genes by HDAC1, including atrogin-1, which required deacetylation of FoxO3a. Moreover, pharmacological inhibition of class I HDACs during muscle disuse, using MS-275, significantly attenuated both disuse muscle fiber atrophy and contractile dysfunction. Together, these data solidify the importance of class I HDACs in the muscle atrophy program and indicate that class I HDAC inhibitors are feasible countermeasures to impede muscle atrophy and weakness.

show abstract

Generalised muscle weakness in young adults with congenital heart disease

Abstract: Respiratory and skeletal muscle weakness is common in young adults with complex CHD and similar to that found in older adults with advanced heart failure from acquired heart disease.

Cited by 112 publications

References 29 publications

Comprehensive Use of Cardiopulmonary Exercise Testing Identifies Adults With Congenital Heart Disease at Increased Mortality Risk in the Medium Term

Comprehensive Use of Cardiopulmonary Exercise Testing Identifies Adults With Congenital Heart Disease at Increased Mortality Risk in the Medium Term

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy

Contact Info

Product

Resources

About