Generalised pustular psoriasis: response to topical calcipotriol.

Berth‐Jones, J.; Bourke, Jane; Bailey, Kristi; Graham‐Brown, R.A.C.; Hutchinson, P.E.

doi:10.1136/bmj.305.6858.868

Cited by 30 publications

(9 citation statements)

References 2 publications

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“…Active vitamin D 3 has regulatory effects on the production of inflammatory cytokines (8)(9)(10). Topical vitamin D 3 ointment has been approved for the treatment of pustulosis including pustular psoriasis (11,12). In contrast, a single case report has mentioned topical ca1cipotriene cream as a possible precipitating factor in pustular psoriasis (13).…”

Section: Discussionmentioning

confidence: 99%

A Case of Subcorneal Pustular Dermatosis Treated with Tacalcitol (1α,24‐Dihydroxyvitamin D₃)

Kawaguchi

Mitsuhashi

Kondô

2000

The Journal of Dermatology

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We report a case of subcorneal pustular dermatosis (SPD) treated with tacalcitol (1alpha,24-Dihydroxyvitamin D3) ointment. A 77-year-old male had had asymptomatic, superficial, grouped pustules in annular patterns with mild background erythema for six years which affected his axillae and bilateral groin. A diagnosis of SPD was made. Topical vitamin D3 (tacalcitol) was applied to the lesion of SPD and its clinical effectiveness was assessed. Within one month, symptoms in the lesion treated with tacalcitol ointment started subsiding, and eventually only erythema remained. After three months, the region treated with tacalcitol ointment showed no relapse. We conclude that tacalcitol ointment is effective for SPD in some case.

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Section: Discussionmentioning

confidence: 99%

A Case of Subcorneal Pustular Dermatosis Treated with Tacalcitol (1α,24‐Dihydroxyvitamin D₃)

Kawaguchi

Mitsuhashi

Kondô

2000

The Journal of Dermatology

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“…The effects are well documented in several clinical trials. However, few reports indicate that calcipotriol can be used in other clinical presentations of the disease such as generalised pustular psoriasis [83] and erythrodermic psoriasis [66,72].…”

Section: Tacalcitol and Maxacalcitolmentioning

confidence: 99%

Recent Developments in Vitamin D Analogs

Fogh

Kragballe²

2000

CPD

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Within the past decade it has been shown that psoriasis can be treated topically with analogs of vitamin-D3. Impaired differentiation and increased proliferation of keratinocytes are key features in psoriatic lesions together with a local activation of T lymphocytes. Evidence has accumulated showing that analogs of vitamin D3 increase differentiation and inhibit proliferation of keratinocytes. Therefore, analogs of vitamin D3 have been investigated in a number of trials showing improvement of psoriasis. It has been shown that vitamin D analogs are better than their vehicle and show the same potency as potent topical steroids. However, vitamin D analogs have been proven efficacious and without side effects also when used on long term basis. Vitamin D analogs can be used both as monotherapy and in combination topical steroids, UVB, PUVA, retinoids and cysclosporine. The vitamin D3 analog calcipotriol has been investigated in most detail and is available as an ointment, a creme and as a scalp solutation. From clinical studies involving thousands of patients, it can be concluded that calcipotriol is efficacious, safe, well tolerated and can be used on a long term basis. Other analogs are available, however, these analogs have not been studied in greater details yet.

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“…The efficacy of topical calcipotriol (50 μg/g), a synthetic vitamin D 3 analog, was first reported in 1992. 9 Since then, topical calcipotriol has become one modality for treating pustular psoriasis, although there were two reports implicating topical calcipotriol as a possible precipitating factor of the condition. 10,11 Because our patient is still young, we selected topical application of a low concentration of vitamin D 3 (2 μg/g tacalcitol) and a weak class of corticosteroid instead of oral retinoid or cyclosporin.…”

Section: Juvenile Pustular Psoriasis Associated With Steroid Withdrawmentioning

confidence: 99%

“…Various treatments such as topical steroids, oral retinoid, methotrexate, cyclosporine, and psoralen and ultraviolet A therapy have been used for this disease. The efficacy of topical calcipotriol (50 µg/g), a synthetic vitamin D 3 analog, was first reported in 1992 9 . Since then, topical calcipotriol has become one modality for treating pustular psoriasis, although there were two reports implicating topical calcipotriol as a possible precipitating factor of the condition 10,11 .…”

mentioning

confidence: 99%

Juvenile pustular psoriasis associated with steroid withdrawal syndrome due to topical corticosteroid

Saeki¹,

Watanabe²,

Tada³

et al. 2008

The Journal of Dermatology

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Generalised pustular psoriasis: response to topical calcipotriol.

Cited by 30 publications

References 2 publications

A Case of Subcorneal Pustular Dermatosis Treated with Tacalcitol (1α,24‐Dihydroxyvitamin D₃)

A Case of Subcorneal Pustular Dermatosis Treated with Tacalcitol (1α,24‐Dihydroxyvitamin D₃)

Recent Developments in Vitamin D Analogs

Juvenile pustular psoriasis associated with steroid withdrawal syndrome due to topical corticosteroid

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Generalised pustular psoriasis: response to topical calcipotriol.

Cited by 30 publications

References 2 publications

A Case of Subcorneal Pustular Dermatosis Treated with Tacalcitol (1α,24‐Dihydroxyvitamin D3)

A Case of Subcorneal Pustular Dermatosis Treated with Tacalcitol (1α,24‐Dihydroxyvitamin D3)

Recent Developments in Vitamin D Analogs

Juvenile pustular psoriasis associated with steroid withdrawal syndrome due to topical corticosteroid

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A Case of Subcorneal Pustular Dermatosis Treated with Tacalcitol (1α,24‐Dihydroxyvitamin D₃)

A Case of Subcorneal Pustular Dermatosis Treated with Tacalcitol (1α,24‐Dihydroxyvitamin D₃)