2022
DOI: 10.1186/s13063-022-06470-y
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Generalizability and reach of a randomized controlled trial to improve oral health among home care recipients: comparing participants and nonparticipants at baseline and during follow-up

Abstract: Background The generalizability of randomized controlled trials (RCTs) with a low response can be limited by systematic differences between participants and nonparticipants. This participation bias, however, is rarely investigated because data on nonparticipants is usually not available. The purpose of this article is to compare all participants and nonparticipants of a RCT to improve oral health among home care recipients at baseline and during follow-up using claims data. … Show more

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Cited by 6 publications
(2 citation statements)
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“…It is more the rule than the exception that RCTs enroll unique subpopulations of the universe of patients in need of the treatments being investigated by the RCTs. Examples include treatment for hypertension, 18 cognitive impairment, 19 bipolar disorder, 20 HIV, 21 , 22 mouth disorders, 23 and many other disease states. 24 To incorporate RCT findings into clinical practice recommendations, it is essential that their results be assessed for generalizability.…”
Section: Discussionmentioning
confidence: 99%
“…It is more the rule than the exception that RCTs enroll unique subpopulations of the universe of patients in need of the treatments being investigated by the RCTs. Examples include treatment for hypertension, 18 cognitive impairment, 19 bipolar disorder, 20 HIV, 21 , 22 mouth disorders, 23 and many other disease states. 24 To incorporate RCT findings into clinical practice recommendations, it is essential that their results be assessed for generalizability.…”
Section: Discussionmentioning
confidence: 99%
“…Once identi ed, then larger trials, with integral process evaluations can be conducted [21]. Especially a low response makes RCTs prone to systematic differences between participants and non-participants, affecting generalizability [22]. As recruitment and retention rates of a large-scale trial can differ from the pilot study, an additional strategy in the development phase of an intervention is pre-emptively generating strategies to address potential recruitment and retention di culties via focus groups and interviews with the target group [23].…”
Section: Discussionmentioning
confidence: 99%