Generalizability of Clinical Trial Results for Generalized Anxiety Disorder to Community Samples

Abstract

Clinical trials exclude a majority of adults with GAD. Clinical trials should carefully consider the impact of eligibility criteria on the generalizability of their results.

Why does the lifetime prevalence of major depressive disorder in the elderly appear to be lower than in younger adults? Results from a national representative sample

“…Regarding sampling, the truncation of the severity spectrum of physical disorders if individuals with important physical disorders are less likely to be interviewed could have lead to underestimate the association between physical disorders and MDD (Hoertel et al, 2012b(Hoertel et al, , 2012c, particularly more in older adults (Schuster et al, 2012). In addition, physical disorders were assessed with a checklist, while mental disorders were assessed with a structured diagnostic interview, possibly leading to an overlap between estimated diagnoses of mental and physical disorders, since physical disorders and depression have in common several symptoms (e.g., asthenia, insomnia).…”

Toward National Estimates of Effectiveness of Treatment for Substance Use

“…17–22 The NESARC has been previously used by our group and others to estimate the a priori generalizability of clinical trials of several psychiatric disorders. 4–6,23–29 The NESARC research protocol received approval from the Institutional Review Boards of the US Office of Management and Budget and the US Census Bureau.…”

Predictors of outcome in outpatients with anxiety disorders: The Leiden routine outcome monitoring study

“…However, generalizability of research findings to patients seen in everyday clinical practice is often limited (Hoertel et al, 2012). This lack of generalizability could result from the use of strict ine and exclusion criteria (Tyrer et al, 2004;Chavira et al, 2009;RoyByrne et al, 2003;Roy-Byrne et al, 2006;Van Ameringen et al, 2004), the focus on a single treatment modality (Telch et al, 2011;Van Ameringen et al, 2004;Serretti et al, 2009) and the focus on a narrowly defined patient group (Beutel et al, 2011;Chavira et al, 2009;Roy-Byrne et al, 2003;Roy-Byrne et al, 2006;Telch et al, 2011;Beard et al, 2010;Van Ameringen et al, 2004).…”