Generalized allergic reaction in response to exercise due to strawberry gibberellin-regulated protein: a case report

Inuo, Chisato; Okazaki, Fumiko; Shiraki, Rie; Tanaka, Yutaka; Momma, Keiko; Kondo, Yasuto; Narita, Hiroshi

doi:10.1186/s13223-022-00692-0

Cited by 13 publications

(4 citation statements)

References 14 publications

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“…Unfortunately, we were not able to achieve functional reductions of CD38 in the cell lines used in the present study (C4-2B and PC3); therefore, it is possible that other players participate in the signaling. Furthermore, there are known ABA inhibitors in plants, including gibberellins, which can in some cases serve as allergens and of which derivatives may have anti-neoplastic activities (71)(72)(73)(74)(75)(76)(77). Whether equivalent proteins function in human systems remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Abscisic acid signaling through LANCL2 and PPARγ induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells

Parajuli,

Jung,

Taichman

2024

Oncol Rep

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Prostate cancer (PCa) is one the most common malignancies in men. The high incidence of bone metastasis years after primary therapy suggests that disseminated tumor cells must become dormant, but maintain their ability to proliferate in the bone marrow. Abscisic acid (ABA) is a stress response molecule best known for its regulation of seed germination, stomal opening, root shoot growth and other stress responses in plants. ABA is also synthesized by mammalian cells and has been linked to human disease. The aim of the present study was to examine the role of ABA in regulating tumor dormancy via signaling through lanthionine synthetase C-like protein 2 (LANCL2) and peroxisome proliferator activated receptor γ (PPARγ) receptors. ABA signaling in human PCa cell lines was studied using targeted gene knockdown (KD), western blotting, quantitative PCR, cell proliferation, migration, invasion and soft agar assays, as well as co-culture assays with bone marrow stromal cells. The data demonstrated that ABA signaling increased the expression of p21, p27 and p16, while inhibiting viability, migration, invasion and colony size in a reversable manner without toxicity. ABA also induced p38MAPK activation and NR2F1 signaling. Targeted gene KD of LANCL2 and PPARγ abrogated the cellular responses to ABA. Taken together, these data demonstrate that ABA may induce dormancy in PCa cell lines through LANCL2 and PPARγ signaling, and suggest novel targets to manage metastatic PCa growth.

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Section: Discussionmentioning

confidence: 99%

Abscisic acid signaling through LANCL2 and PPARγ induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells

Parajuli,

Jung,

Taichman

2024

Oncol Rep

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“…Recently, a GRP allergen in strawberry was considered responsible for an exercise-induced systemic allergic reaction in a patient also allergic to Japanese cedar pollen, and a similar case caused by grape GRP has also been reported [12,13]. Sensitization to fruit GRP is often observed alongside sensitization to Cupressaceae pollen in both Europe and Japanese cedar pollen in Japan, however, it is unclear whether the primary sensitizer is the pollen or fruit [14].…”

Section: Novel Fruit and Vegetable Allergensmentioning

confidence: 99%

New arrivals in anaphylaxis to foods

Olivieri

Skypala

2023

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review More people are excluding wheat from their diet, or turning to a more sustainable diet in which includes meat substitutes or is mainly or wholly plant-based. This increases the availability of new foods and with it the increasing likelihood of novel allergens. Recent findings There is a growing body of evidence which suggests that allergies to seeds and legumes are increasing potentially due to their use in concentrated form in vegan or health foods. Insects can be a sustainable source of protein, but mealworm could provoke symptoms in individuals sensitized or allergic to shellfish or house dust mite. Novel plant food allergens such as gibberellin-regulated proteins and thaumatin-like proteins are increasingly being reported as significant causes of severe reactions to fruits. Summary these findings make it even more imperative to take a full dietary history to ensure apparent idiopathic anaphylaxis is not in reality due to a novel food, especially in cases where other forms of the food are tolerated. Given the lack of diagnostic tests for these novel foods, a prick-to-prick skin prick test should be performed with the suspected food. There is currently more work needed to define and sequence many of the allergens involved.

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“…Several workers in strawberry greenhouse have workrelated symptoms and sensitize strawberry pollen, but not all workers are necessarily sensitized to Fra a 1. Recently, another new allergen, gibberellin-regulated protein from strawberries was case reported [27]. We should be careful not to misinterpret these symptoms as OAS by Fra a 1.…”

Section: Expression Patterns Of Fra a 1 Paralogs In Strawberry Plantsmentioning

confidence: 99%

Characteristics of major allergen Fra a 1 in cultivated strawberry

2023

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Cultivated strawberry (Fragaria× ananassa) is a fruity vegetable of the Rosaease family and contains allergens which cause oral allergic syndrome (OAS). OAS is a type I allergy mediated by IgE, and as the symptoms appear in the oral cavity, hypoallergenic fruits are eagerly anticipated. The major allergen in strawberry OAS is Fra a 1-an ortholog of the birch pollen allergen Bet v 1. It is necessary to understand the characteristics of Fra a 1 in planta to properly regulate Fra a 1 accumulation and produce safe edible fruits. In this review, we summarize the Fra a 1 expression patterns in strawberries and this allergenicity in birch patients' IgE. Additionally, we describe the cultivar differences and environmental responses of Fra a 1 and discuss the proper regulation of Fra a 1 in order to produce hypoallergenic fruits.

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Generalized allergic reaction in response to exercise due to strawberry gibberellin-regulated protein: a case report

Cited by 13 publications

References 14 publications

Abscisic acid signaling through LANCL2 and PPARγ induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells

Abscisic acid signaling through LANCL2 and PPARγ induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells

New arrivals in anaphylaxis to foods

Characteristics of major allergen Fra a 1 in cultivated strawberry

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