Generalized cognitive dysfunction, symptomatology, and specific cognitive processes in relation to functioning of schizophrenia patients

Sponheim, Scott R.; Surerus-Johnson, Christa; Dieperink, Michael E.; Spoont, Michele

doi:10.1016/s0920-9964(02)00524-8

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…Neurocognitive domains of interest 3, 4 have been expanded still further in cognitive neuroscience-based initiatives, such as the ongoing CNTRICS (Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia) initiative, which incorporates processes such as sensory gain and integration alongside more neuropsychologically driven domains 5 . Nevertheless, the relationship between lower and higher levels of dysfunction, as well as the neural substrates underlying these domains, remains an area of active research.…”

Section: Introductionmentioning

confidence: 99%

Impaired Visual Object Processing Across an Occipital-Frontal-Hippocampal Brain Network in Schizophrenia

Sehatpour

Dias

Butler

et al. 2010

Arch Gen Psychiatry

128

123

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Background Perceptual closure refers to the ability to identify objects with partial information. Deficits in schizophrenia are indexed by impaired generation of the closure-related negativity (NCL) from ventral stream visual cortex (lateral occipital complex, LOC), as part of a network of brain regions that also includes dorsal stream visual regions, prefrontal cortex (PFC) and hippocampus. This study evaluates network-level interactions during perceptual closure in schizophrenia using parallel ERP, fMRI and neuropsychological assessment. Methods ERP were obtained from 24 patients and 20 healthy volunteers in response to fragmented (closeable) and control scrambled (noncloseable) line drawings. fMRI were obtained from 11 patients and 12 controls. Patterns of between group differences for predefined ERP components and fMRI regions of interest were determined using both analysis of variance and structural equation modeling. Global neuropsychological performance was assessed using elements of the WAIS-III, WMS-III and MATRICS batteries. Results Patients showed impaired visual P1 generation, reflecting dorsal stream dysfunction, along with impaired generation of NCL components over PFC and LOC. In fMRI, patients showed impaired activation of dorsal and ventral visual regions, PFC and hippocampus. Impaired activation of dorsal stream visual regions contributed significantly to impaired PFC activation. Impaired PFC activation contributed significantly to impaired activation of hippocampus and LOC. Impaired LOC and hippocampal activation contributed significantly to deficits on WAIS-III Perceptual Organization Index (POI) and other tests of impaired perceptual processing in schizophrenia. Conclusion Schizophrenia is associated with severe activation deficits across a distributed network of sensory and higher order cognitive regions. Deficit in early visual processing within the dorsal visual stream contributes significantly to impaired frontal activation which, in turn, leads to dysregulation of hippocampus and ventral visual stream. Dysfunction within this network underlies impairment in more traditional measures of neurocognitive dysfunction such as POI, supporting distributed models of brain dysfunction in schizophrenia.

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Section: Introductionmentioning

confidence: 99%

Impaired Visual Object Processing Across an Occipital-Frontal-Hippocampal Brain Network in Schizophrenia

Sehatpour

Dias

Butler

et al. 2010

Arch Gen Psychiatry

128

123

View full text Add to dashboard Cite

show abstract

“…Huppert and Smith's 23 finding that hallucinations were also related to self-reported obsessive-compulsive disorder (OCD) symptoms leads to a broader possibility: neurophysiologically, there may be an overlap between OCD symptoms and positive symptoms such as seen in schizophrenia, because the neural circuits known to relate to both types include the orbitofrontal cortex and the anterior cingulate cortex (ACC). 24,25 Several studies show an association between thought disorders and cognitive impairment, [26][27][28] which suggests a common neurobiological substrate for both dysfunctions. Additionally, a meta-analysis by Kerns and Berenbaum 29 revealed a correlation between formal thought disorders (FTDs) and executive functions, and connections between thought disorders and semantic memory.…”

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confidence: 99%

Treating Thought Disorders

Surmeli¹

2014

Clinical Neurotherapy

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Facial expressivity during the clinical interview as a predictor functional disability in schizophrenia. A pilot study

Troisi

Pompili²,

Binello³

et al. 2007

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Generalized cognitive dysfunction, symptomatology, and specific cognitive processes in relation to functioning of schizophrenia patients

Cited by 8 publications

References 9 publications

Impaired Visual Object Processing Across an Occipital-Frontal-Hippocampal Brain Network in Schizophrenia

Impaired Visual Object Processing Across an Occipital-Frontal-Hippocampal Brain Network in Schizophrenia

Treating Thought Disorders

Facial expressivity during the clinical interview as a predictor functional disability in schizophrenia. A pilot study

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