In this paper, we focus on the (σ, τ)-derivation theory of Lie conformal superalgebras. Firstly, we study the fundamental properties of conformal (σ, τ)-derivations. Secondly, we mainly research the interiors of conformal G-derivations. Finally, we discuss the relationships between the conformal (σ, τ)-derivations and some generalized conformal derivations of Lie conformal superalgebras.