Let R be a semi prime ring. Suppose that , are automorphisms on R. A symmetric bi-additive mapping is said to be a generalized symmetric reverse bi-(????, )-derivation on R if there exists a symmetric reverse bi-(????, )-derivation D on R such that ) = + (v)D( holds . Let ] and ] be two generalized symmetric reverse bi-(????, )-derivations of R with associated reverse bi- -derivations . In this paper, we establish some equivalent conditions for the orthogonality between two symmetric generalized reverse bi-(????, )-derivations of semiprime ring R.