Generalized dermatitis due to oral ephedrine

Martinez, F. Villas; Badas, A. Joral; Goitia, J. F. Garmendia; Aguirre, I. Bilbao

doi:10.1111/j.1600-0536.1993.tb03546.x

Cited by 15 publications

(3 citation statements)

References 6 publications

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“…Although sympathomimetic drugs are widely used, allergic reactions to ephedrine are rarely reported, especially when the drugs are administered systemically . Sensitization to ephedrine in our patient had probably been induced by its earlier use during the first papilloma operation.…”

Section: Commentmentioning

confidence: 72%

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Ephedrine‐induced maculopapular rash

2018

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Section: Commentmentioning

confidence: 72%

“…Sensitization to ephedrine in our patient had probably been induced by its earlier use during the first papilloma operation. Some cases of contact sensitivity and systemic reactions to pseudoephedrine have been reported, but only a few cases of widespread dermatitis caused by oral ephedrine …”

Section: Commentmentioning

confidence: 99%

Ephedrine‐induced maculopapular rash

2018

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“…Adverse drug reactions due to pseudoephedrine not only include numerous cases of pigmented [116,117] and non-pigmented skin eruptions [118][119][120], but also some generalized scarlatiniform [121] or eczematous eruptions [122][123][124]. Moreover, cases of recurrent acute generalized exanthematous pustulosis and severe mucosal involvement have been described [125].…”

Section: Clinical Datamentioning

confidence: 99%

In search of an ideal drug for safer treatment of obesity: The false promise of pseudoephedrine

Munafò

Frara

Perico

et al. 2021

Rev Endocr Metab Disord

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Obesity is a major public health problem worldwide. Only relatively few treatment options are, at present, available for the management of obese patients. Furthermore, treatment of obesity is affected by the widespread misuse of drugs and food supplements. Ephedra sinica is an old medicinal herb, commonly used in the treatment of respiratory tract diseases. Ephedra species contain several alkaloids, including pseudoephedrine, notably endowed with indirect sympathomimetic pharmacodynamic properties. The anorexigenic effect of pseudoephedrine is attributable primarily to the inhibition of neurons located in the hypothalamic paraventricular nucleus (PVN), mediating satiety stimuli. Pseudoephedrine influences lipolysis and thermogenesis through interaction with β3 adrenergic receptors and reduces fat accumulation through down-regulation of transcription factors related to lipogenesis. However, its use is associated with adverse events that involve to a large extent the cardiovascular and the central nervous system. Adverse events of pseudoephedrine also affect the eye, the intestine, and the skin, and, of relevance, sudden cardiovascular death related to dietary supplements containing Ephedra alkaloids has also been reported. In light of the limited availability of clinical data on pseudoephedrine in obesity, along with its significantly unbalanced risk/benefit profile, as well as of the psychophysical susceptibility of obese patients, it appears reasonable to preclude the prescription of pseudoephedrine in obese patients of any order and degree.

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Drug Reactions

Breathnach¹

2004

Rook's Textbook of Dermatology

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Generalized dermatitis due to oral ephedrine

Cited by 15 publications

References 6 publications

Ephedrine‐induced maculopapular rash

Ephedrine‐induced maculopapular rash

In search of an ideal drug for safer treatment of obesity: The false promise of pseudoephedrine

Drug Reactions

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