Generalized eruptive keratoacanthoma of Grzybowski: Response to cyclophosphamide

Generalized Eruptive Keratoacanthoma of Grzybowski: Follow-Up of the Original Description and 50-Year Retrospect

“…Systemic chemotherapy with methotrexate seems to be of limited efficacy and not entirely safe. One patient was reported to show good response to systemic cyclophosphamide [41]; however, this therapy does not seem to be safe. Intravenous 5-fluorouracil was found to be of some effectiveness for larger nodular lesions, but its use has been associated with pronounced toxicity [42].…”

Cyclophosphamide in dermatology

“…108,109 In three patients unresponsive to acitretin, complete remission was observed after six cycles of monthly CPT (1 g) in two patients who had disease durations of 5-7 years and were also unresponsive to MTX. 110 …”

Generalized eruptive keratoacanthomas of Grzybowski

“…18,19 Yet, due to the significant potential side effects of cyclophosphamide, including a dose-related risk of leukemic disorders and hemorrhagic cystitis, investigators recommend that use of this drug should be employed only when other treatment modalities have been exhausted. 18 Conclusions Generalized eruptive keratoacanthomas of Grzybowski is a rare variant of keratoacanthoma, presenting with hundreds of small, umbilicated keratinous papules. The condition typically affects adults in the fifth to seventh decades of life, with equal preponderance for men and women.…”

“…7 The significant difference between idiopathic keratoacanthomas and those associated with Grzybowski tumors is the very large number of small lesions in the latter condition; therefore the term generalized eruptive keratoacanthomas of Grzybowski is commonly used in reference to this variant. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Epidemiology…”