Generalized giant lymph follicle hyperplasia of lymph nodes and spleen

Brill, N. E.; Baehr, George; Rosenthal, Nathan

doi:10.1016/0002-9343(52)90023-5

Cited by 29 publications

(9 citation statements)

References 2 publications

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“…It is perhaps important to remember that many of the so‐called first cases and series of cases were often reported by physicians who were not distinguished, and the authors are often forgotten. Some of the most remarkable first reports were: preinvasive carcinoma (carcinoma in situ) of the uterus,89 metastatic rhabdomyosarcoma,90 parosteal sarcoma,37 thymic tumors in association with myasthenia gravis,91 primitive neuroectodermal tumor,92 follicular lymphoma,93 oat cell carcinoma of the lung,94 malignant meningioma,95 microinvasive duct carcinoma of the breast,96 pleural mesothelioma,97 malignant melanoma of the eye,98 carcinoma of the bladder,99 primary lung carcinoma,100 biphasic and monophasic synovial sarcoma,101 chordoid tumor of the palm,102 extramammary Paget's disease,103 Ewing's sarcoma of soft tissues,104 and classification tumors of the testis 105…”

Section: Chronology Of Discoveries First Descriptions New Terms Anmentioning

confidence: 99%

A note from history: Landmarks in history of cancer, part 5

Hajdu

Darvishian

2013

Cancer

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In the 3 decades from 1910 to 1940, more progress took place in cancer research and the diagnosis and treatment of cancers than during the prior centuries combined. The discovery of several carcinogens, precancerous conditions, and hereditary cancers adduced new thoughts about the genesis of cancers. Even though diagnostic radiology and radiation therapy became apposite specialties, surgery retained its primacy in the treatment of cancer patients. The delineation of new and distinct neoplastic entities, several precancerous lesions, and noninvasive carcinomas as well as the introduction of histopathologic grading of cancers promulgated cogent changes in therapy. Yet, with all the advances in the diagnosis and treatment of cancers, very little betterment could be demonstrated in the overall survival of patients, and by the end of the 1930s, cancer became the second most common cause of death in the United States. Cancer 2013. © 2012 American Cancer Society.

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Section: Chronology Of Discoveries First Descriptions New Terms Anmentioning

confidence: 99%

A note from history: Landmarks in history of cancer, part 5

Hajdu

Darvishian

2013

Cancer

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“…The first description of follicular lymphoma was by Brill, Baehr, and Rosenthal from Mount Sinai Hospital in New York City in 1925 [4]. They reported two young patients, aged 28 and 32, who presented with lymphadenopathy and massive splenomegaly.…”

Section: Initial Descriptions Of Follicular Lymphomamentioning

confidence: 99%

“…In other words, when a patient presented with a tumor that was not readily accessible for biopsy or surgery, radiation was administered and response was considered indicative of a diagnosis of lymphoma. In general, responses of lymphoma to radiation were incomplete and short lived, but follicular lymphoma had a higher incidence of complete and prolonged responses [4,7]. Even today, radiation remains a valuable tool in the treatment of follicular lymphoma, particularly in stage I and stage II disease, where radiation, sometimes combined with chemotherapy, is considered a curative form of therapy [38 -41].…”

Section: Treatment For Follicular Lymphomamentioning

confidence: 99%

Follicular lymphoma: a historical overview

Besien

Schouten

2007

Leukemia & Lymphoma

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Lymphoma was first described in 1862 and follicular lymphoma in 1925. Initially considered a benign disorder, and named Brill - Symmers disease after the authors of the original papers, it was rapidly recognized as a malignancy with a variable but often indolent course. Most of its clinical features were described by the early 1940s. Despite discussion about its cell of origin, and in contrast to many other lymphoma subtypes, follicular lymphoma could always be accurately recognized and diagnosed using light microscopy morphological features. B-cell origin was demonstrated in the 1970s and the important role of t(14;18) and bcl-2 gene rearrangement in the pathogenesis of follicular lymphoma was established shortly thereafter. The etiology of follicular lymphoma, the reason for marked geographic variation in its incidence, the role of alternative molecular pathways in its pathogenesis, and the cause for its variable clinical behavior all remain unknown. Several observations suggest an important role for the normal immune response in regulating the clinical behavior of follicular lymphoma. From the earliest descriptions, radiation therapy was shown to be very effective in follicular lymphoma, but not curative. Combination chemotherapy was tested in the 1970s, but despite high rates of response, there was only minimal impact on survival. Interferon combined with anthracycline based chemotherapy was the first treatment to improve survival, but was not widely adopted in the USA. Randomized studies have shown an impact of autologous transplantation on progression free survival. Allogeneic transplantation is a curative therapy, but is too toxic for widespread application. Targeted therapies, particularly rituximab have revolutionized the treatment of follicular lymphoma. A convergence of technological and biological advances will likely lead to further dramatic progress in the next decade. For the first time consistent improvements in survival of follicular lymphoma are reported.

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“…However, it was well into the twentieth century before order began to emerge from the heterogeneous non‐Hodgkin's lymphomas. The follicular or nodular lymphomas were first clearly described by Brill et al (1925) , initially without recognition of the malignant character of the proliferation. However, within a few years both these authors and Symmers (1927) were convinced that the condition was a malignant, albeit indolent, growth.…”

Section: The Delineation Of the Non‐hodgkin's Lymphomasmentioning

confidence: 99%

Historical review of lymphomas

Aisenberg

2000

Br J Haematol

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Generalized giant lymph follicle hyperplasia of lymph nodes and spleen

Cited by 29 publications

References 2 publications

A note from history: Landmarks in history of cancer, part 5

A note from history: Landmarks in history of cancer, part 5

Follicular lymphoma: a historical overview

Historical review of lymphomas

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