There are different types of order relations that are associated with interval analysis for determining integral inequalities. The purpose of this paper is to connect the inequalities terms to total order relations, often called (CR)-order. In contrast to classical interval-order relations, total order relations are quite different and novel in the literature and are calculated as ω=⟨ωc,ωr⟩=⟨ω¯+ω̲2,ω¯−ω̲2⟩. A major benefit of total order relations is that they produce more efficient results than other order relations. This study introduces the notion of CR-(h1,h2)-convex function using total order relations. Center and Radius order relations are a powerful tool for studying inequalities based on their properties and widespread application. Using this novel notion, we first developed some variants of Hermite–Hadamard inequality and then constructed Jensen inequality. Based on the results, this new concept is extremely useful in connection with a variety of inequalities. There are many new and well-known convex functions unified by this type of convexity. These results will stimulate further research on inequalities for fractional interval-valued functions and fuzzy interval-valued functions, as well as the optimization problems associated with them. For the purpose of verifying our main findings, we provide some nontrivial examples.