People are preoccupied with their own duties in today's environment, making it tough to oversee and care for disabled people. Paralyzed and disabled people, on the other hand, have a powerful desire to move around freely. Different initiatives have been taken in the past to improve and preserve the self-esteem of such people, and various technologies have also been created to assist them in a better way. The primary advantage of a vision-based autonomous wheelchair is that it can provide greater independence to users with limited mobility. The methodology of other smart wheelchairs varies depending on the specific technology used. Some smart wheelchairs may use sensors to detect obstacles and provide feedback to the user, while others may incorporate GPS and other navigation technologies to assist with indoor and outdoor navigation. Our study proposes a revolutionary implementation of an autonomous system for fully handicapped people, allowing them to drive wheelchairs using just their eyes. The wheelchair's orientation will be determined by the orientation of the eye. The camera will follow the movement of the eyes. Furthermore, sensors will be installed on the front side of the wheelchair to identify any obstacles along its path. The calibration of the camera with the human eye, without obstructing its vision, is the most challenging task in this research, besides controlling the wheels of the wheelchair.