Generalized idiopathic neutrophilic eccrine hidradenitis in a 7-month-old child

Pseudomonas-Contaminated Pool Triggering an Episode of Idiopathic Palmoplantar Hidradenitis

“…Neutrophilic eccrine hidradenitis is found mainly in patients with leukemia and other neoplastic diseases but can also arise secondary to chemotherapy drugs [ 21 ]. Affected locations are usually random and include the trunk, face, and extremities; most lesions present as tender erythematous papules and have extra histopathological features that differentiate them from IPPH [ 1 , 12 , 22 ]. Hand-foot disease from enteroviruses usually presents with asymptomatic vesicular lesions on the hands, feet, and oral cavity [ 3 ].…”

“…Histopathologic examination will reveal a primarily neutrophilic inflammatory infiltrate surrounding eccrine sweat glands [ 8 , 25 ]. Neutrophilic eccrine hidradenitis can be differentiated from IPPH by the presence of necrotic eccrine glands, syringosquamous metaplasia, and neutrophilic infiltrates affecting the ductal and secretory components of the eccrine coils with or without eosinophilic deposits in the basement membrane of the eccrine duct [ 1 , 12 , 21 , 22 ]. Histopathologic examination of IPPH will reveal inflammatory infiltrates surrounding the ductal component of eccrine coils and, frequently, neutrophilic abscesses adjacent to eccrine coils with or without septal panniculitis [ 1 , 12 , 21 , 22 ].…”

Neutrophilic eccrine hidradenitis secondary to pegfilgrastim in a patient with synovial sarcoma

“…It has been suggested that G‐CSF induced NEH occurs secondary to enhanced chemotaxis of neutrophils and stimulation of neutrophilic progenitors . In healthy children with NEH, destruction of immature eccrine glands by high temperatures with resultant inflammatory infiltrate has been proposed as an additional pathogenetic mechanism . Another hypothesis is that NEH may be a hypersensitivity reaction within the spectrum of other neutrophilic dermatoses such as Sweet syndrome…”

Neutrophilic superficial eccrine ductitis: Proposal of a new disease concept

“…Most cases of NEH have been reported in patients with acute myelogenous leukemia or other hematologic malignancies who have undergone treatment with different chemotherapeutic regimens . NEH has also been reported in healthy children, although only in a small number of cases . All reported cases of childhood NEH occurred in patients younger than 2 years during the summer.…”