Generalized Lichen Nitidus in Russell‐Silver Syndrome

Abstract

Generalized lichen nitidus is a rare disease, and there are only a few reports associating it with a genetic disorder. Here we report a case of generalized lichen nitidus in Russell-Silver syndrome.

A Case of Generalized Pruritic Lichen Nitidus with Palmoplantar Involvement - Pediatric Generalized Lichen Nitidus

“…The exact etiology of LN is unknown, but familial occurrence has been reported, suggesting a possible genetic predisposition, which could possibly render individuals susceptible to some environmental factors that induce the eruption [8] Generalized LN has also been reported in association with genetic disorders such as Down syndrome [9,10] and Russel-Silver syndrome [11]. In our case, family history and physical examination were negative for any genetic or other related disorders.…”

Generalized lichen nitidus associated with neurofibromatosis type 1 and juvenile myelomonocytic leukemia

“…Differential diagnosis of lichen nitidus including other lichenoid dermatoses such as lichen planus, follicular eczema, and sometimes molluscum contagiosum . The generalized form of lichen nitidus in childhood has been reported to be associated with several diseases, including Down syndrome, Russell–Silver syndrome, and Niemann–Pick disease . However, predisposing factors of lymphohistiocytic infiltration within the papillary dermis in these associations could not be defined.…”

“…Lichen nitidus is an uncommon asymptomatic eruption mainly seen in children . The generalized form of lichen nitidus in childhood has been reported to be associated with several diseases, including Down syndrome, Russell–Silver syndrome, and Niemann–Pick disease . Herein, a patient with neurofibromatosis type 1 (NF1) and juvenile myelomonocytic leukemia (JMML), diagnosed as generalized lichen nitidus, is presented.…”

Generalized Lichen Nitidus in a boy with Niemann-Pick disease type B

“…1 Generalized LN has occasionally been reported in association with genetic disorders: Down syndrome (four cases) 2 and Russell-Silver syndrome (one case). 3 No causative link was found between these associations. Further studies are needed to clarify if this association is merely coincidental, since Down syndrome is quite common in the general population.…”