Generalized lymphadenopathy caused by Trichosporon asahii in a patient with Job's syndrome

Chakrabarti, A.; Marhawa, R. K.; Mondal, R.; Trehan, A.; Gupta, S.; Rao, D. S. V. Raman; Sethi, S.; Padhye, A. A.

doi:10.1080/714031075

Cited by 8 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Crude mortality rates were 30% for children and 87.5% for adult patients (P ϭ 0.025) (24,25). Finally, small series of cases of invasive trichosporonosis have also been described for burn victims, patients with secondary hemochromathosis, and Job's syndrome (23,26,73,162).…”

Section: Deep-seated Infectionsmentioning

confidence: 99%

“…However, despite being less frequent, there are increasing reports of episodes of organ-specific infections and patients with disseminated trichosporonosis presenting with pneumonia, soft tissue lesions and eventually endophthalmitis, endocarditis, brain abscess, meningitis, arthritis, esophagitis, lymphadenopathy, liver, splenic abscess, and uterine infections (23,24,26,27,74,98,110,117,154,178).…”

Section: Deep-seated Infectionsmentioning

confidence: 99%

See 1 more Smart Citation

Current Knowledge of Trichosporon spp. and Trichosporonosis

2011

View full text Add to dashboard Cite

SUMMARY Trichosporon spp. are basidiomycetous yeast-like fungi found widely in nature. Clinical isolates are generally related to superficial infections. However, this fungus has been recognized as an opportunistic agent of invasive infections, mostly in cancer patients and those exposed to invasive medical procedures. It is possible that the ability of Trichosporon strains to form biofilms on implanted devices, the presence of glucuronoxylomannan in their cell walls, and the ability to produce proteases and lipases are all factors likely related to the virulence of this genus and therefore may account for the progress of invasive trichosporonosis. Disseminated trichosporonosis has been increasingly reported worldwide and represents a challenge for both diagnosis and species identification. Phenotypic identification methods are useful for Trichosporon sp. screening, but only molecular methods, such as IGS region sequencing, allow the complete identification of Trichosporon isolates at the species level. Methods for the diagnosis of invasive trichosporonosis include PCR-based methods, Luminex xMAP technology, and, more recently, proteomics. Treating patients with trichosporonosis remains a challenge because of limited data on the in vitro and in vivo activities of antifungal drugs against clinically relevant species of the genus. Despite the mentioned limitations, the use of antifungal regimens containing triazoles appears to be the best therapeutic approach.

show abstract

Section: Deep-seated Infectionsmentioning

confidence: 99%

Section: Deep-seated Infectionsmentioning

confidence: 99%

Current Knowledge of Trichosporon spp. and Trichosporonosis

2011

View full text Add to dashboard Cite

show abstract

“…The 287 infections we assigned to the category of Trichosporon spp. included 28 cases (all reported after 1995) in which the yeast was identified, in accordance with the revised classification, as T. asahii (17 infections, including 10 in patients with hematological diseases) (1,16,26,36,58,81,84,98,131,132, plus 6 cases from the present series); T. inkin (5 infections, 2 in patients with hematological malignancies) (19,72,74,84,104); T. mucoides (4 infections, none involving patients with hematological malignancies) (45,92); and T. cutaneum or T. asteroides (each responsible for 1 infection, both involving patients with hematological malignancies) (18,66). The vast majority of G. capitatum and T. pullulans infections occurred in patients with hematological disease (91.7 and 75%, respectively).…”

Section: Methodsmentioning

confidence: 99%

Invasive Infections Caused byTrichosporonSpecies andGeotrichum capitatumin Patients with Hematological Malignancies: a Retrospective Multicenter Study from Italy and Review of the Literature

Girmenia¹,

Pagano

Martino³

et al. 2005

J Clin Microbiol

362

391

View full text Add to dashboard Cite

Trichosporonosis is an uncommon but frequently fatal mycosis in immunocompromised patients 8 and 91.7%, respectively). Well over half of these were suffering from acute leukemia (68 and 84% of patients with Trichosporon sp. and G. capitatum infections, respectively). Crude mortality rates were 77% for Trichosporon spp. and 55.7% for G. capitatum. The optimal therapy for trichosporonosis has yet to be identified; however, in vitro experiences are providing encouraging evidence of the potential role of the new triazoles, in particular, voriconazole.

show abstract

“…In 1990s, two cases of invasive trichosporonosis were reported in India, again in immunocompromised individuals [12,13].…”

Section: Discussionmentioning

confidence: 99%