Generalized neonatal herpes virus infection (cytomegalovirus or herpes virus type 1) comparative examination of loci attacked by two viruses^3,4

Abstract

Two autopsy cases, a 5-minute-old male infant with congenital cytomegalovlrus (CMV) infection and a 10-day-old female infant with herpes simplex virus type 1 (IISV-1) infection, were presented. CMV antibody titer detectable by immunofluorescence (IF) technique was significantly high in the sera of both Infant and mother in the CMV case. In another HSV-1 case, we have succeeded in HSV-1 isolation from autopsy liver and subsequent serological identification of the isolated virus, including a detection of high HSV-1 antibody titer in the mother's serum by IF. On light and electron microscopes, these two cases respectively showed typical findings as the severest form of each viral Infection. As one of the marked differences between the two cases, the thymus in the IISV-1 case showed remarkable involution with a complete disappearance of thymic cortical lymphocytes. However, the CMV case exhibited an existence of Intact thymus without viral injuries. Similar dlstinguishable differences between the two cases were observed also In the bone marrow. It additionally seems to be unique that cytomegalic inclusion bodies were disclosed fairly well in the submaxillary glands and rarely in the renal tubules even In the case with Case Reports Case 1. A male infant after 31 week's gestation was delivered to a 26-year-old primigravida by Caesarian section because of earlier rupture of fetal membrane and prolapse of cord caused by breech presentation. The infant was mildly asphyxia1 a t birth and had Apgar score 5, but soon after he became worse and died in 5 minutes in spite of resuscitative efforts. The mother had been uneventful during pregnancy except for slight fever of 37.5"~ a t 8 weeks' gestation. 34(4): 1984K WATANABE el 01. 849

Pseudorabies virus hijacks DDX3X, initiating an addictive “mad itch” and immune suppression, to facilitate viral spread

“…Importantly, herpes viruses have been shown to induce thymic atrophy in chicken (Gimeno et al, 2011), cattle (Romero-Palomo et al, 2015), seals (Gulland et al, 1997) and also in a case study in a human neonate (Watanabe et al, 1984). PRV infection has also previously been linked to thymic atrophy (Narita and Ishi, 2006).…”

My approach to performing a perinatal or neonatal autopsy

“…73 Herpes simplex virus isolated from an autopsy of the liver was serologically detected by immunofluorescence and confirmed by electron microscopy. 74 DNA, mRNA and early antigen for cytomegalovirus can be detected by immunocytochemistry, in situ hybridisation and in situ hybridisation-immunomax on autopsy of tissues. Early antigen was detected most often.…”