Generalized pustular psoriasis of pregnancy treated with oral cyclosporin

Treatment of pustular psoriasis: From the Medical Board of the National Psoriasis Foundation

“…Data from patients with transplantation along with several case reports indicate that cyclosporine is not associated with an increased risk of adverse effects during the pregnancy at a dose of 2 to 3 mg/kg. 58,62,63 A recent case report documented the efficacy of infliximab. 48 With a category B pregnancy status and rapid onset of action, infliximab may offer advantages in acute severe disease.…”

Cyclosporine in the Management of Impetigo Herpetiformis: A Case Report and Review of the Literature

“…Cyclosporine has been administered in 13 patients with IH in the literature [6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17]. Reviewing the above-mentioned cases, in 12 out of 14 cases, including ours, cyclosporine was not used as a monotherapy in the treatment of IH but in combination with systemic corticosteroids (table 1).…”

Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP

“…Overseas, cyclosporin has been used in several cases of impetigo herpetiformis to control the acute symptoms in combination with steroids and later as a post-therapy medication to manage the symptoms until the delivery of the child. 53,[168][169][170] In cases of organ transplantation, where cyclosporin was administrated to pregnant women post-transplant, the odds ratio for teratogenicity was 3.83 (95% confidence interval [CI], 0.75-19.6), and the incidence of teratogenicity was 4.1% (95% CI, 2.6-7%), with no statistically significant difference, revealing no evidence for teratogenesis. 50,171,172 When patients with GPP have marked generalized edema or complication of ARDS/capillary leak syndrome, it is desirable to use systemic steroids (20-40 mg/day of prednisolone equivalent) as the first-line drug.…”