Generalized quasi-linear mixed-effects model

Saigusa, Yusuke; Eguchi, Shinto; Komori, Osamu

doi:10.1177/09622802221085864

Cited by 7 publications

(4 citation statements)

References 42 publications

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“…[35][36][37][38] The P2/P1 ratios were analyzed using a mixed linear model with random effects in four groups: MV patients (COVID-19 and non-COVID-19), nonmechanically ventilated COVID-19 patients, and healthy volunteers. [39][40][41] The P2/P1 ratio was obtained from the average of all valid pulses each minute; all results outside 0.5 to 1.8 were considered artifactual and excluded.…”

Section: Discussionmentioning

confidence: 99%

Intracranial compliance in patients with COVID-19: a multicenter observational study

Silveira,

Santos,

Collange

et al. 2024

Arq Neuropsiquiatr

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Background Patients with severe coronavirus disease-19 (COVID-19) may require the use of invasive mechanical ventilation (MV) for prolonged periods. Aggressive MV parameters have been associated with changes in intracranial pressure (ICP) in patients with acute intracranial disorders. Significant ICP elevation could compromise intracranial compliance (ICC) and cerebrovascular hemodynamics (CVH). However, the effects of these parameters in individuals without neurological disorders have not yet been evaluated. Objective To evaluate ICC in patients on MV with COVID-19 infection compared to other diagnoses, to better characterize the effects of MV and COVID-19 upon ICC. We also compared between the ICC in patients with COVID-19 who did not require MV and healthy volunteers, to assess the isolated effect of COVID-19 upon ICC. Methods This was an exploratory, observational study with a convenience sample. The ICC was evaluated with a noninvasive ICP monitoring device. The P2/P1 ratio was calculated by dividing the amplitude of these two points, being defined as “abnormal” when P2 > P1. The statistical analysis was performed using a mixed linear model with random effects to compare the P2/P1 ratio in all four groups on the first monitoring day. Results A convenience sample of 78 subjects (15 MV-COVID-19, 15 MV non-COVID-19, 24 non-MV-COVID-19, and 24 healthy participants) was prospectively enrolled. There was no difference in P2/P1 ratios between MV patients with and without COVID-19, nor between non-MV patients with COVID-19 and healthy volunteers. However, the P2/P1 ratio was higher in COVID-19 patients with MV use than in those without it. Conclusion This exploratory analysis suggests that COVID-19 does not impair ICC.

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Section: Discussionmentioning

confidence: 99%

Intracranial compliance in patients with COVID-19: a multicenter observational study

Silveira,

Santos,

Collange

et al. 2024

Arq Neuropsiquiatr

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“…The prognosis was compared using the Kaplan-Meier method (K-M) to display the decreased survival rate free from composite endpoints, and the difference was analyzed using the log-rank test. In addition, the generalized linear mixed-effects models (GLMMs) [14] were constructed to evaluate the association of repeatedly measured eGFR and proteinuria between two cohorts and among the different follow-up periods, and compared using analysis of variance (ANO-VA). The GLMM could better illustrate the fixed effect of the independent variable on the dependent variable when there are random effects such as individual differences.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Persistent Hematuria Degrees in Primary IgA Nephropathy: A Propensity Score-Matched Analysis of a 10-Year Follow-Up Cohort

Huang¹,

Zhang²,

Chen³

et al. 2023

Am J Nephrol

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Introduction: The clinical significance of persistent hematuria degrees hasn't been expounded in primary IgA nephropathy (IgAN) and requires further research. Methods: From January 2003 to May 2022, a total of 684 IgAN patients with persistent hematuria were enrolled to conduct a retrospective single-center study. Patients whose hematuria degree at baseline was higher than the second tertiles of the whole were included in the high-degree hematuria cohort (Hh), and the low-degree hematuria cohort (Lh) was constructed with 1:1 matched cases from the rest according to age, gender, estimated glomerular filtration rate (eGFR) at baseline and follow-up time. Survival was determined using the Kaplan–Meier method (K-M) and generalized linear mixed-effects model (GLMM). Risk factors for survival were determined according to the Cox proportional hazards model. Results: Both the Hh and Lh consisted of 228 cases. While the demographic data and the renal function at baseline were matched, both the K-M (p=0.02) and GLMM (p=0.04) proved that the prognosis of the Hh was significantly worse than that of the Lh within 10 years of follow-up. The higher persistent hematuria degree was an independent risk factor (3.93; 95% confidence interval, 1.33 to 11.6) associated with reaching the endpoint (eGFR decreased from the baseline ≥ 30% continuously or reached end-stage renal disease [ESRD]). The Hh had a significantly higher proportion of crescent (p=0.003). The prognosis of the Hh was significantly worse than that of the Lh when accompanied by the crescent and presented an indistinct difference if the crescent was absent. Conclusion: The clinicopathologic manifestation of IgAN patients with persistent high-degree hematuria was severer and the prognosis was worse than those with persistent low-degree hematuria.

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“…To account for the interdependence of TEPS within each patient, we used generalized mixed models. 22 To analyze the association with…”

Section: Discussionmentioning

confidence: 99%

“…We analyzed the relationship between the PM and TEPS at each lumbar level. To account for the interdependence of TEPS within each patient, we used generalized mixed models 22 . To analyze the association with TEPS at T1, we used a univariable and multivariable linear mixed model and adjusted for relevant confounders: age, sex, body mass index (BMI), diabetes mellitus, hypertension, and smoking status.…”

Section: Methodsmentioning

confidence: 99%

Understanding the Interplay Between Paraspinal Muscle Atrophy and Lumbar Endplate Degeneration

Schönnagel,

Zhu,

Guven

et al. 2023

Spine

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Study Design. Retrospective analysis of longitudinal data. Objective. To assess the association between the paraspinal musculature (PM) and lumbar endplate degeneration. Background. The PM is essential for spinal stability, while the vertebral endplate is pivotal for nutrient transport and force distribution. The clinical importance of both has been highlighted in recent literature, though little is known about their interaction. Methods. We identified patients with lumbar MRI scans due to low back pain, with a 3-year interval between MRI scans. Endplate damage was assessed by the total endplate score (TEPS) at each lumbar level. The PM was evaluated for its functional cross-sectional area (fCSA) and fatty infiltration (FI) at the L4 level. We used a generalized mixed model to analyze the association between PM parameters and TEPS at timepoint one, adjusting for age, sex, BMI, diabetes, hypertension, and smoking status. The association with the progression of endplate damage was analyzed through an ordinal regression model, additionally adjusted for TEPS at baseline. Results. 329 patients were included, with a median follow-up time of 3.4 years. Participants had a median age of 59 and a BMI of 25.8 kg/m2. In the univariate analysis, FI of the posterior PM was significantly associated with TEPS at baseline (β: 0.08, P<0.001) and progression of TEPS (OR: 1.03, P=0.020) after adjustment for confounders. The β and OR in this analysis are per percent of FI. In a binary analysis, patients with FI ≥ 40% had an OR of 1.92 (P=0.006) for the progression of TEPS. Conclusions. This is the first longitudinal study assessing the relationship between PM and endplate degeneration, demonstrating the association between PM atrophy and progression of endplate degeneration. This insight may aid in identifying patients at risk for degenerative lumbar conditions and guide research into preventive measures.

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Generalized quasi-linear mixed-effects model

Cited by 7 publications

References 42 publications

Intracranial compliance in patients with COVID-19: a multicenter observational study

Intracranial compliance in patients with COVID-19: a multicenter observational study

Clinical Significance of Persistent Hematuria Degrees in Primary IgA Nephropathy: A Propensity Score-Matched Analysis of a 10-Year Follow-Up Cohort

Understanding the Interplay Between Paraspinal Muscle Atrophy and Lumbar Endplate Degeneration

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