Generalized seizure with falling and unresponsive staring provoked by somatosensory stimulation: a video‐EEG study*

Abstract

We report a 4‐year‐old boy with generalized seizures with abrupt falling and unresponsive staring provoked by somatosensory stimuli of the face. Ictal manifestation comprised a sudden fall immediately after wiping the face, followed by unresponsive staring for around 10 seconds, during which time the video‐EEG recorded paroxysmal 3‐Hz diffuse spike‐wave complexes, which were followed by high‐voltage 3.5 to 4‐Hz delta wave discharges, predominantly appearing in the bilateral frontal areas. Seizures were not controlled by clonazepam, valproate or levetiracetam, but were successfully treated with lamotrigine added to valproate. This type of generalized reflex seizure has so far not been reported in the literature. [Published with video sequence]

Stimulus-induced Epileptic Spike-Wave Discharges in Thalamocortical Model with Disinhibition

“…Alternative therapies to reduce the SWD discharges of absence seizure are need to be further explored. To some extent, stimulus perturbations can control or suppress the epileptic seizures 202425262728293031323334, which can offer a potential alternative to the traditional therapy with antiepileptic drugs. Specifically, both the epileptic humans and animal models, as well as the theoretical model20, have been conducted to investigate the feasibility of stimulation for aborting brain activities related to the absence seizures with SWD discharges35.…”