Generalized Yersinia enterocolitica Infection

Rabson, A R; Hallett, A. F.; Koornhof, H. J.

doi:10.1093/infdis/131.4.447

Cited by 178 publications

(52 citation statements)

References 12 publications

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“…The clinical picture varies from asymptomatic cases to sepsis and death (Verhaegen et al 1985). Most hematogenous infections with Y. enterocolitica are seen in patients with disturbances in blood-forming organs (Rabson et al 1975).…”

Section: Discussionmentioning

confidence: 99%

“…The condition affects both minor and major joints (Ejlertsen 1988). The third category of symptoms is caused by hematogenous spread of the bacteria, mostly in patients with an underlying illness, such as diabetes mellitus, liver diseases, or blood disorders (Rabson et al 1975, Butzler et al 1979, and Bissett 1976.…”

Section: Yersinia Enterocolitica Coxitis After Hip Replacement a Casementioning

confidence: 99%

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Yersinia enterocoliticacoxitis after hip replacement: A case report

Hougaard¹,

Søgaard

1990

Acta Orthopaedica Scandinavica

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Section: Discussionmentioning

confidence: 99%

Section: Yersinia Enterocolitica Coxitis After Hip Replacement a Casementioning

confidence: 99%

Yersinia enterocoliticacoxitis after hip replacement: A case report

Hougaard¹,

Søgaard

1990

Acta Orthopaedica Scandinavica

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“…An iron-overloaded state promotes systemic spread by facilitating growth of these organisms and thwarting phagocytic killing and other immune system functions. The clinical course of Y. enterocolitica septicemia may include liver and spleen abscesses (12), empyema (2), endocarditis (8), and septic arthritis (4). Occasional cases of bacteremia have been linked to transfusion of contaminated blood products (13).…”

Section: Case Reportmentioning

confidence: 99%

Axillary Abscess Due to Yersinia enterocolitica

Menzies

2010

J Clin Microbiol

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Yersinia enterocolitica rarely causes extraintestinal disease. A 54-year-old construction worker with chronic hepatitis C developed an axillary abscess following an injury to his finger. An aspirate from the axillary mass grew Y. enterocolitica. Direct inoculation is proposed as the mode of transmission of this classically enteric pathogen. CASE REPORTA 54-year-old African-American construction worker presented to an outpatient clinic associated with our academic tertiary referral center in early January 2009 with a painful "lump" at the right axilla of 2 days' duration. His medical history was significant for chronic hepatitis C without clinical decompensation. At the initial visit, the patient also pointed out a healing pustule on a finger of his right hand which he had recently self-debrided with a razor. The pustule had developed from a poorly healing wound from splinter trauma during a visit to a landfill 2 months earlier. He felt otherwise well, and he had no fever. Application of warm compresses to the axilla was recommended. One week later, he returned to his primary care provider with complaints of increasing pain and size of the right axillary mass as well as fever and night sweats. The temperature was 100.3°F. On examination, there was a palpable tender mass the size of approximately one-half of a tennis ball with mild overlying erythema but no fluctuance. The remainder of his examination was normal. The peripheral leukocyte count was 15,400 cells/mm 3 . Ultrasound imaging indicated an encapsulated mass of 8.0 cm by 5.5 cm by 5.4 cm with a largely cystic necrotic center. Gram stain of an aspirated specimen indicated 4ϩ white blood cells and no organisms. After 24 h of incubation, the culture yielded pure culture of a non-lactosefermenting Gram-negative bacillus that was identified as Yersinia enterocolitica, using the Vitek GNI identification system (bioMérieux, Hazelwood, MO), with 99.00% probability, and motility tests (motile at room temperature but not at 35°C). Identity was confirmed with 16S rRNA gene sequencing. There were three to five colonies each on sheep blood and MacConkey agar plates in addition to a positive broth culture. No blood or stool culture was ordered or performed. Sensitivity studies using the Vitek 2 instrument showed susceptibility to ceftazidime, ceftriaxone, imipenem, aminoglycosides, ciprofloxacin, levofloxacin, and trimethoprim-sulfamethoxazole; the isolate was resistant to ampicillin, ampicillin-sulbactam, and cefazolin. Upon further interview, the patient denied any abdominal pain or diarrhea. He also denied consumption or exposure to pork chitterlings or other raw pork products in recent weeks. The mass resolved on a 4-week oral regimen of trimethoprim-sulfamethoxazole, and he made a full recovery.

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“…Extraintestinal and systemic infections are most often caused by strains belonging to so-called highvirulence serotypes, such as serotype O8 (Heesemann et al, 1993), although low-virulence serotypes, such as O3 and O9, may occasionally cause bactaeremia in patients with iron overload or other underlying diseases (Rabson et al, 1975 ;Bouza et al, 1980). The presence of a 70 kb plasmid (pYV) that carries a number of virulence genes is required for Y. enterocolitica strains to become virulent (Cornelis et al, 1998).…”

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confidence: 99%

Intestinal infection of BALB/c mice with Yersinia enterocolitica O9 causes major modifications in phenotype and functions of spleen cells

2001

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INTRODUCTIONYersinia enterocolitica is a common cause of intestinal infections in humans (Cover & Aber, 1989 ;Bottone, 1997). Extraintestinal and systemic infections are most often caused by strains belonging to so-called highvirulence serotypes, such as serotype O8 (Heesemann et al., 1993), although low-virulence serotypes, such as O3 and O9, may occasionally cause bactaeremia in patients with iron overload or other underlying diseases (Rabson et al., 1975 ;Bouza et al., 1980). The presence of a 70 kb plasmid (pYV) that carries a number of virulence genes is required for Y. enterocolitica strains to become virulent (Cornelis et al., 1998).Non-septic sequelae of human yersiniosis include reactive arthritis, erythema nodosum, Reiter's syndrome, autoimmune thyroiditis and other immunopathological complications (Winblad, 1973 ;Bech et al., 1974 ;Toivanen et al., 1985). Alterations in the immune networks following infection with a number of microorganisms are likely to play a role in the genesis of immunopathological diseases (Schwartz, 1993). The effects of experimental yersiniosis on immunity parameters, such as the size of spleen cell subsets or the production of immune cytokines, have been documented in mice infected with serotype O8 strains (Autenrieth et al., 1994 ; Bohn et al., 1998). In comparison, lowvirulence serotypes have received little attention, although they possess immunomodulatory properties (Ruiz-Bravo et al., 1985. In humans, enteric colonization with low-virulence serotypes may persist for periods of up to 14 weeks without symptoms (Morris et al., 1991) ; however, there is no information available about the possible effects of the intestinal carriage of these strains on the immune condition of the hosts. In this study, we used a murine intestinal infection model (Ruiz-Bravo et al., 1999) A. RUIZ-BRAVO, E. MORENO and M. JIME; NEZ-VALERA of mice infected with a low-virulence serotype of Y. enterocolitica. METHODSMice. Six-to eight-week-old female BALB\c mice were provided by the Unit of Animal Experimentation, University of Granada (Granada, Spain). They were maintained under pathogen-free conditions. Experimental infection with Y. enterocolitica. Strain IP383 of Y. enterocolitica was used in all experiments. It is a serotype O9 strain that carries the virulence plasmid pYV (Mazigh et al., 1983). Bacteria were grown on Tryptic soy agar (Difco) at 25 mC for 24 h, harvested, washed and resuspended in sterile water to obtain 10* bacteria ml − ". Mice were infected via the oral route, as described previously (Ruiz-Bravo et al., 1999). Phenotypic analysis of spleen cells. Spleens were homogenized in PBS containing 1 % (w\v) BSA (Sigma). Splenocytes were sedimented by centrifugation, resuspended in red blood cell lysing buffer (Sigma) for 10 min, washed and resuspended in PBS containing BSA. Cell suspensions from individual mice were adjusted to 10( viable cells ml − ". Aliquots (100 µl) were incubated with 5 µl fluorescein-isothiocyanate-conjugated monoclonal antibodies. The monoclonal antibodies use...

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Generalized Yersinia enterocolitica Infection

Cited by 178 publications

References 12 publications

Yersinia enterocoliticacoxitis after hip replacement: A case report

Yersinia enterocoliticacoxitis after hip replacement: A case report

Axillary Abscess Due to Yersinia enterocolitica

Intestinal infection of BALB/c mice with Yersinia enterocolitica O9 causes major modifications in phenotype and functions of spleen cells

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