In this paper we define and study the global Hilbert-Kunz multiplicity and the global F-signature of prime characteristic rings which are not necessarily local. Our techniques are made meaningful by extending many known theorems about Hilbert-Kunz multiplicity and F-signature to the non-local case.1 Now let R be an F-finite domain, not necessarily local. With the above observation, we define the global Hilbert-Kunz multiplicity of R, still denoted e HK (R), as e HK (R) = lim e→∞ µ(F e * R)/ rank(F e * R), provided the limit exists. Our first main result is the existence of the corresponding limit for any F-finite ring. In addition, we relate e HK (R) with the Hilbert-Kunz multiplicities e HK (R P ) of the localizations at primes P ∈ Spec(R), showing that such an invariant, even though it is defined globally, captures the local properties of the ring. Finally, as for the Hilbert-Kunz multiplicity of a local ring, we show that small values of e HK (R) imply that R has mild singularities. We summarize all these results in the following theorem. We point out that our results hold in a more general setup than the one in which we state them here, as we will show in Section 3.The inequality in the middle follows from the fact that the minimal number of generators of the T -module F e * M ′ can only decrease after localization at the prime Q. 6 7