Generating Diversity and Specificity through Developmental Cell Signaling

Hoch, Renée V.; Soriano, Philippe

doi:10.1016/b978-0-12-405945-0.00001-6

Cited by 1 publication

(1 citation statement)

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“…The consequent knowledge will pay great dividends in understanding how growth factors dictate cellular behaviors, laying the requisite foundation for studying how such processes can be pathologically corrupted. More broadly, the conceptual frameworks and emerging technologies outlined above can likely be expanded beyond RTKs to any number of signaling events during development (Hoch & Soriano, 2015), and insights gleaned across the full range of signaling processes in the embryo will further our understanding of the critical parameters underlying cellular decision making.…”

Section: Discussionmentioning

confidence: 99%

A Thousand and One Receptor Tyrosine Kinases

Vasudevan

Soriano

2016

Current Topics in Developmental Biology

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Over twenty years ago, a series of seminal studies in PC12 neurons provided a framework for how receptor tyrosine kinases generate many different outcomes despite activating a set of shared intracellular pathways. In this essay, we revisit the question of receptor tyrosine kinase specificity. We first examine the relationship between receptor phosphorylation and intracellular pathway activation. We then consider the mechanisms through which signaling dynamics encode distinct cellular outcomes and finally discuss how two different receptors drive divergent transcriptional responses within the same developmental context. Establishing the key parameters that dictate the response to growth factor stimulation is critical for determining how receptor tyrosine kinases orchestrate development, an essential prerequisite for understanding the pathological consequences when such signaling processes go awry.

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Section: Discussionmentioning

confidence: 99%