Premium wine production is limited to regions climatically conducive to growing grapes with balanced composition and varietal typicity. Three central climatic conditions are required: (i) adequate heat accumulation; (ii) low risk of severe frost damage; and (iii) the absence of extreme heat. Although wine production is possible in an extensive climatic range, the highest-quality wines require a delicate balance among these three conditions. Although historical and projected average temperature changes are known to influence global wine quality, the potential future response of wineproducing regions to spatially heterogeneous changes in extreme events is largely unknown. Here, by using a high-resolution regional climate model forced by the Intergovernmental Panel on Climate Change Special Report on Emission Scenarios A2 greenhouse gas emission scenario, we estimate that potential premium winegrape production area in the conterminous United States could decline by up to 81% by the late 21st century. While increases in heat accumulation will shift wine production to warmer climate varieties and͞or lower-quality wines, and frost constraints will be reduced, increases in the frequency of extreme hot days (>35°C) in the growing season are projected to eliminate winegrape production in many areas of the United States. Furthermore, grape and wine production will likely be restricted to a narrow West Coast region and the Northwest and Northeast, areas currently facing challenges related to excess moisture. Our results not only imply large changes for the premium wine industry, but also highlight the importance of incorporating fine-scale processes and extreme events in climate-change impact studies.climate change ͉ enology ͉ grape ͉ viticulture ͉ winegrape A number of observations indicate that warming has occurred during the late 20th and early 21st centuries at the Earth's surface (1), in the troposphere (2-4), and in the oceans (5). The majority of this warming has likely been caused by anthropogenic greenhouse gas (GHG) emissions (6), and if such emissions continue unabated, global mean temperatures are likely to rise by 2-6°C over the next century (1). This mean global warming will likely manifest itself over a range of spatial and temporal scales, altering mean seasonal climate (e.g., ref. 7), interannual climate variability (e.g., ref. 8), and the frequency and magnitude of extreme events (e.g., refs. 9-11).Such climatic changes could have a wide variety of important impacts on sectors such as human health (12), biological invasions (13), species extinctions (14), and water (15) and energy (16) resources. Because the quality and production of cultivated crops are directly influenced by local climate variables, agricultural systems may be particularly susceptible to climate change. For at least five reasons, the cultivation of grapes for the production of premium wine provides an optimal case for assessing potential impacts of climate change. First, premium wines are produced conterminously with human habitation an...