Prognosis and remaining useful life (RUL) estimation of components and systems (C&S) are vital for intelligent asset-integrity management. The implementation of the traditional multi-level particle filter (TRMPF) has improved prognosis when compared with the one-step traditional particle filter that depended on the first-order state equation. However, despite this improvement, the need to enhance the accuracy of fault prognosis, diagnosis and detection cannot be overemphasized. To this end, an optimal multi-level particle filter (OPMPF) algorithm that combines genetic algorithm (GA) optimization and multi-level particle filter (MPF) techniques is used to predict the RUL of the C&S in order to enhance the accuracy of the estimation at different forms of deterioration in operation. A 9-fold cross-validation ensemble MPF that utilized lithium-ion (Li +) batteries' charge capacity decay to test the developed OPMPF algorithm showed an improvement of over 200% in the estimated RUL when compared with the TRMPF estimation.