2002
DOI: 10.1053/rvsc.2001.0523
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Generation and activity of equine osteoclasts in vitro: effects of the bisphosphonate pamidronate (APD)

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Cited by 18 publications
(14 citation statements)
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“…Osteoclasts, which are specialized monocyte/macrophage family members derived from bone marrow hematopoietic precursors [21], are the principal (if not exclusive) resorptive cells of bone [28]. RANKL and M-CSF are essential for the formation of osteoclasts [14]. …”
Section: Introductionmentioning
confidence: 99%
“…Osteoclasts, which are specialized monocyte/macrophage family members derived from bone marrow hematopoietic precursors [21], are the principal (if not exclusive) resorptive cells of bone [28]. RANKL and M-CSF are essential for the formation of osteoclasts [14]. …”
Section: Introductionmentioning
confidence: 99%
“…Biphosphonates, such as tiludronate, are drugs that reduce bone resorption and have proven very effective in human medicine. In equine osteoclast-like cells generated from bone marrow, the inhibitory function of bisphosphonates has been confirmed (Gray et al 2002), and in horses with navicular disease the drug appears to be effective (Denoix et al 2003).…”
Section: Treatment: Evidence-based Treatments and Improved Results Frmentioning
confidence: 99%
“…In particular, stromal expression of macrophage colony-stimulating factor (M-CSF) and the receptor activator of NFB ligand (RANKL) are necessary and sufficient to induce osteoclastogenesis in vivo and in vitro. 275,276 M-CSF, through binding to its receptor c-Fms, acts as a survival factor for osteoclast precursor cells, allowing them to respond to inducers of osteoclastogenesis. 277 Expression of membrane-bound RANKL is induced in stromal cells and osteoblasts by various stimuli, including parathyroid hormone (PTH), PTH related protein (PTHrP), calcitriol, tumor necrosis factor-␣ (TNF-␣), glucocorticoids, prostaglandin E2 (PGE2), IL-1, IL-11, bFGF, and IGF-1.…”
Section: Epithelial To Mesenchymal Transition (Emt) Of Prostate Cancementioning
confidence: 99%