Generation and characterization of avian single chain variable fragment against human Alpha-Enolase

Lee, Chi Hsin; Tsai, Ching Wen; Leu, Sy-Jye; Liu, Ko‐Jiunn; Wang, Wei-Chu; Tsai, Bor-Yu; Chiang, Liao-Chun; Mao, Yan‐Chiao; Dlamini, Nhlanhla; Tsai, Chen-Hsin; Yang, Yi Yuan

doi:10.1016/j.intimp.2023.110277

International Immunopharmacology

2023

DOI: 10.1016/j.intimp.2023.110277

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Generation and characterization of avian single chain variable fragment against human Alpha-Enolase

Chi Hsin Lee

Ching Wen Tsai

Sy-Jye Leu

et al.

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2024

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Monoclonal IgY antibodies: advancements and limitations for immunodiagnosis and immunotherapy applications

Tabll,

Shahein,

Omran

et al. 2024

Therapeutic Advances in Vaccines and Immunotherapy

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Due to their high specificity and scalability, Monoclonal IgY antibodies have emerged as a valuable alternative to traditional polyclonal IgY antibodies. This abstract provides an overview of the production and purification methods of monoclonal IgY antibodies, highlights their advantages over polyclonal IgY antibodies, and discusses their recent applications. Monoclonal recombinant IgY antibodies, in contrast to polyclonal IgY antibodies, offer several benefits. such as derived from a single B-cell clone, monoclonal antibodies exhibit superior specificity, ensuring consistent and reliable results. Furthermore, it explores the suitability of monoclonal IgY antibodies for low- and middle-income countries, considering their cost-effectiveness and accessibility. We also discussed future directions and challenges in using polyclonal IgY and monoclonal IgY antibodies. In conclusion, monoclonal IgY antibodies offer substantial advantages over polyclonal IgY antibodies regarding specificity, scalability, and consistent performance. Their recent applications in diagnostics, therapeutics, and research highlight their versatility.

show abstract

Monoclonal IgY antibodies: advancements and limitations for immunodiagnosis and immunotherapy applications

Tabll,

Shahein,

Omran

et al. 2024

Therapeutic Advances in Vaccines and Immunotherapy

View full text Add to dashboard Cite

show abstract

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Generation and characterization of avian single chain variable fragment against human Alpha-Enolase

Cited by 1 publication

References 48 publications

Monoclonal IgY antibodies: advancements and limitations for immunodiagnosis and immunotherapy applications

Monoclonal IgY antibodies: advancements and limitations for immunodiagnosis and immunotherapy applications

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